Cargando…

Targeting Class A and C Serine β-Lactamases with a Broad-Spectrum Boronic Acid Derivative

[Image: see text] Production of β-lactamases (BLs) is the most widespread resistance mechanism adopted by bacteria to fight β-lactam antibiotics. The substrate spectrum of BLs has become increasingly broad, posing a serious health problem. Thus, there is an urgent need for novel BL inhibitors. Boron...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tondi, Donatella, Venturelli, Alberto, Bonnet, Richard, Pozzi, Cecilia, Shoichet, Brian K., Costi, Maria Paola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079326/ https://www.ncbi.nlm.nih.gov/pubmed/24882105 http://dx.doi.org/10.1021/jm5006572

Ejemplares similares

Virtual screening identifies broad-spectrum β-lactamase inhibitors with activity on clinically relevant serine- and metallo-carbapenemases
por: Spyrakis, Francesca, et al.
Publicado: (2020)

Computational and biological profile of boronic acids for the detection of bacterial serine- and metallo-β-lactamases
por: Santucci, Matteo, et al.
Publicado: (2017)

Permeation through the Cell Membrane of a Boron-Based β-Lactamase Inhibitor
por: Minozzi, Manuela, et al.
Publicado: (2011)

Discovery of Taniborbactam (VNRX-5133): A Broad-Spectrum Serine- and Metallo-β-lactamase Inhibitor for Carbapenem-Resistant Bacterial Infections
por: Liu, Bin, et al.
Publicado: (2019)

Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases
por: Krajnc, Alen, et al.
Publicado: (2019)

Structural basis of metallo-β-lactamase, serine-β-lactamase and penicillin-binding protein inhibition by cyclic boronates
por: Brem, Jürgen, et al.
Publicado: (2016)

Cyclic Boronates Inhibit All Classes of β-Lactamases
por: Cahill, Samuel T., et al.
Publicado: (2017)

VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in Enterobacterales and Pseudomonas aeruginosa
por: Hamrick, Jodie C., et al.
Publicado: (2020)

Durlobactam, a Broad-Spectrum Serine β-lactamase Inhibitor, Restores Sulbactam Activity Against Acinetobacter Species
por: Papp-Wallace, Krisztina M, et al.
Publicado: (2023)

Phenylboronic Acids Probing Molecular Recognition against Class A and Class C β-lactamases
por: Linciano, Pasquale, et al.
Publicado: (2019)

4-Amino-1,2,4-triazole-3-thione as a Promising Scaffold for the Inhibition of Serine and Metallo-β-Lactamases
por: Linciano, Pasquale, et al.
Publicado: (2020)

Spectrum of Beta-Lactamase Inhibition by the Cyclic Boronate QPX7728, an Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases: Enhancement of Activity of Multiple Antibiotics against Isogenic Strains Expressing Single Beta-Lactamases
por: Lomovskaya, Olga, et al.
Publicado: (2020)

Broad spectrum antibiotic-degrading metallo-β-lactamases are phylogenetically diverse
por: Pedroso, Marcelo Monteiro, et al.
Publicado: (2020)

Microbiological Characterization of VNRX-5236, a Broad-Spectrum β-Lactamase Inhibitor for Rescue of the Orally Bioavailable Cephalosporin Ceftibuten as a Carbapenem-Sparing Agent against Strains of Enterobacterales Expressing Extended-Spectrum β-Lactamases and Serine Carbapenemases
por: Chatwin, Cassandra L., et al.
Publicado: (2021)

Bismuth antimicrobial drugs serve as broad-spectrum metallo-β-lactamase inhibitors
por: Wang, Runming, et al.
Publicado: (2018)

Can We Exploit β-Lactamases Intrinsic Dynamics for Designing More Effective Inhibitors?
por: Gianquinto, Eleonora, et al.
Publicado: (2020)

Studies on the Reactions of Biapenem with VIM Metallo β-Lactamases and the Serine β-Lactamase KPC-2
por: Lucic, Anka, et al.
Publicado: (2022)

Bicyclic Boronates as Potent Inhibitors of AmpC, the Class C β-Lactamase from Escherichia coli
por: Lang, Pauline A., et al.
Publicado: (2020)

Will morphing boron-based inhibitors beat the β-lactamases?
por: Krajnc, Alen, et al.
Publicado: (2019)

Broad-Spectrum Inhibitors against Class A, B, and C Type β-Lactamases to Block the Hydrolysis against Antibiotics: Kinetics and Structural Characterization
por: Farhat, Nabeela, et al.
Publicado: (2022)

Discovery of an Orally Available Diazabicyclooctane Inhibitor (ETX0282) of Class A, C, and D Serine β-Lactamases
por: Durand-Réville, Thomas F., et al.
Publicado: (2020)

Editorial for the Special Issue: “Targeting β-Lactamases to Fight Bacterial Resistance to β-Lactam Antibiotics”
por: Pozzi, Cecilia
Publicado: (2020)

Discovery of mercaptopropanamide-substituted aryl tetrazoles as new broad-spectrum metallo-β-lactamase inhibitors
por: Yan, Yu-Hang, et al.
Publicado: (2020)

Phenotypic detection of broad-spectrum beta-lactamases in microbiological practice
por: Sedlakova, Miroslava Htoutou, et al.
Publicado: (2011)

Interactions of “Bora-Penicilloates” with Serine β-Lactamases and DD-Peptidases
por: Dzhekieva, Liudmila, et al.
Publicado: (2014)

Acquired Class D β-Lactamases
por: Antunes, Nuno T., et al.
Publicado: (2014)

In silico identification and experimental validation of hits active against KPC-2 β-lactamase
por: Klein, Raphael, et al.
Publicado: (2018)

Biochemical Characterization of QPX7728, a New Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases
por: Tsivkovski, Ruslan, et al.
Publicado: (2020)

Presence of Broad-Spectrum Beta-Lactamase-Producing Enterobacteriaceae in Zoo Mammals
por: De Witte, Chloë, et al.
Publicado: (2021)

Investigations on recyclisation and hydrolysis in avibactam mediated serine β-lactamase inhibition
por: Choi, Hwanho, et al.
Publicado: (2016)

Interaction of Avibactam with Class B Metallo-β-Lactamases
por: Abboud, Martine I., et al.
Publicado: (2016)

In Silico and In Vitro Screening of Natural Compounds as Broad-Spectrum β-Lactamase Inhibitors against Acinetobacter baumannii New Delhi Metallo-β-lactamase-1 (NDM-1)
por: Vasudevan, Aparna, et al.
Publicado: (2022)

Penicillanic Acid Sulfones Inactivate the Extended-Spectrum β-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of β-Lactamase Inhibition
por: Hinchliffe, Philip, et al.
Publicado: (2022)

Isonitrile-Based Multicomponent Synthesis of β-Amino Boronic Acids as β-Lactamase Inhibitors
por: Bassini, Emanuele, et al.
Publicado: (2020)

Detection of Extended-Spectrum β-Lactamases (ESBLs) and AmpC in Class A and Class B Carbapenemase-Producing Enterobacterales
por: Imkamp, Frank, et al.
Publicado: (2022)

Interactions of the Diazabicyclooctane Serine β-Lactamase Inhibitor ETX1317 with Target Enzymes
por: Shapiro, Adam B., et al.
Publicado: (2020)

Metallo-β-Lactamase and Extended-Spectrum-β-Lactamase Production by Serratia Strains [Letter]
por: Singh, Bhoj R, et al.
Publicado: (2020)

In vitro Susceptibility to β-Lactam Antibiotics and Viability of Neisseria gonorrhoeae Strains Producing Plasmid-Mediated Broad- and Extended-Spectrum β-Lactamases
por: Kandinov, Ilya, et al.
Publicado: (2022)

Urban Pigeons (Columba livia) as a Source of Broad-Spectrum β-Lactamase-Producing Escherichia coli in Lisbon, Portugal
por: Freire, Samanta, et al.
Publicado: (2022)

Multidrug-resistant Pseudomonas aeruginosa producing PER-1 extended-spectrum serine-beta-lactamase and VIM-2 metallo-beta-lactamase.
por: Docquier, J D, et al.
Publicado: (2001)

Cannot write session to /tmp/vufind_sessions/sess_csi9h1i9n22m0tr8sialpimer2