Cargando…

Metabolomics Analysis Identifies Intestinal Microbiota-Derived Biomarkers of Colonization Resistance in Clindamycin-Treated Mice

BACKGROUND: The intestinal microbiota protect the host against enteric pathogens through a defense mechanism termed colonization resistance. Antibiotics excreted into the intestinal tract may disrupt colonization resistance and alter normal metabolic functions of the microbiota. We used a mouse mode...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jump, Robin L. P., Polinkovsky, Alex, Hurless, Kelly, Sitzlar, Brett, Eckart, Kevin, Tomas, Myreen, Deshpande, Abhishek, Nerandzic, Michelle M., Donskey, Curtis J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079339/ https://www.ncbi.nlm.nih.gov/pubmed/24988418 http://dx.doi.org/10.1371/journal.pone.0101267

Ejemplares similares

Impact of Tigecycline Versus Other Antibiotics on the Fecal Metabolome and on Colonization Resistance to Clostridium difficile in Mice
por: Jump, Robin L.P., et al.
Publicado: (2017)

A Modified R-Type Bacteriocin Specifically Targeting Clostridium difficile Prevents Colonization of Mice without Affecting Gut Microbiota Diversity
por: Gebhart, Dana, et al.
Publicado: (2015)

1647 Are Hospital Floors an Underappreciated Reservoir for Transmission of Clostridium difficile and Methicillin-Resistant Staphylococcus aureus?
por: Deshpande, Abhishek, et al.
Publicado: (2014)

Evaluation of a hand-held far-ultraviolet radiation device for decontamination of Clostridium difficile and other healthcare-associated pathogens
por: Nerandzic, Michelle M, et al.
Publicado: (2012)

Outpatient Healthcare Settings and Transmission of Clostridium difficile
por: Jury, Lucy A., et al.
Publicado: (2013)

Novel Strategies for Enhanced Removal of Persistent Bacillus anthracis Surrogates and Clostridium difficile Spores from Skin
por: Nerandzic, Michelle M., et al.
Publicado: (2013)

Triggering Germination Represents a Novel Strategy to Enhance Killing of Clostridium difficile Spores
por: Nerandzic, Michelle M., et al.
Publicado: (2010)

Activate to Eradicate: Inhibition of Clostridium difficile Spore Outgrowth by the Synergistic Effects of Osmotic Activation and Nisin
por: Nerandzic, Michelle M., et al.
Publicado: (2013)

Induced Sporicidal Activity of Chlorhexidine against Clostridium difficile Spores under Altered Physical and Chemical Conditions
por: Nerandzic, Michelle M., et al.
Publicado: (2015)

A Quaternary Ammonium Disinfectant Containing Germinants Reduces Clostridium difficile Spores on Surfaces by Inducing Susceptibility to Environmental Stressors
por: Nerandzic, Michelle M., et al.
Publicado: (2016)

Sensitizing Clostridium difficile Spores With Germinants on Skin and Environmental Surfaces Represents a New Strategy for Reducing Spores via Ambient Mechanisms
por: Nerandzic, Michelle M., et al.
Publicado: (2017)

Do medical students receive training in correct use of personal protective equipment?
por: John, Amrita, et al.
Publicado: (2017)

819. How effective is alcohol flush and drying cycle of automatic endoscope reprocessor (AER): Stripped Endoscope (SE) model
por: Yassin, Mohamed, et al.
Publicado: (2020)

A pilot study to assess use of fluorescent lotion in patient care simulations to illustrate pathogen dissemination and train personnel in correct use of personal protective equipment
por: Alhmidi, Heba, et al.
Publicado: (2016)

Sorting through the Wealth of Options: Comparative Evaluation of Two Ultraviolet Disinfection Systems
por: Nerandzic, Michelle M., et al.
Publicado: (2014)

Decreased Ecological Resistance of the Gut Microbiota in Response to Clindamycin Challenge in Mice Colonized with the Fungus Candida albicans
por: Markey, Laura, et al.
Publicado: (2021)

A Cumulative Spore Killing Approach: Synergistic Sporicidal Activity of Dilute Peracetic Acid and Ethanol at Low pH Against Clostridium difficile and Bacillus subtilis Spores
por: Nerandzic, Michelle M., et al.
Publicado: (2015)

Staphylococcus aureus intestinal colonization is associated with increased frequency of S. aureus on skin of hospitalized patients
por: Bhalla, Anita, et al.
Publicado: (2007)

Unique Clindamycin-Resistant Clostridioides difficile Strain Related to Fluoroquinolone-Resistant Epidemic BI/RT027 Strain
por: Skinner, Andrew M., et al.
Publicado: (2020)

Evaluation of an automated ultraviolet radiation device for decontamination of Clostridium difficile and other healthcare-associated pathogens in hospital rooms
por: Nerandzic, Michelle M, et al.
Publicado: (2010)

Reduced Acquisition and Overgrowth of Vancomycin-Resistant Enterococci and Candida Species in Patients Treated With Fidaxomicin Versus Vancomycin for Clostridium difficile Infection
por: Nerandzic, Michelle M., et al.
Publicado: (2012)

Do piperacillin/tazobactam and other antibiotics with inhibitory activity against Clostridium difficile reduce the risk for acquisition of C. difficile colonization?
por: Kundrapu, Sirisha, et al.
Publicado: (2016)

Case report of clindamycin graded challenge in an AIDS patient allergic to clindamycin
por: Raknoo, Thitinun, et al.
Publicado: (2022)

Impact of Intestinal Microbiota on Intestinal Luminal Metabolome
por: Matsumoto, Mitsuharu, et al.
Publicado: (2012)

Defining the Vulnerable Period for Re-Establishment of Clostridium difficile Colonization after Treatment of C. difficile Infection with Oral Vancomycin or Metronidazole
por: Abujamel, Turki, et al.
Publicado: (2013)

Clindamycin suppresses virulence expression in inducible clindamycin-resistant Staphylococcus aureus strains
por: Hodille, Elisabeth, et al.
Publicado: (2018)

Unlocking the Sporicidal Potential of Ethanol: Induced Sporicidal Activity of Ethanol against Clostridium difficile and Bacillus Spores under Altered Physical and Chemical Conditions
por: Nerandzic, Michelle M., et al.
Publicado: (2015)

Effect of Clindamycin on Intestinal Microbiome and Miltefosine Pharmacology in Hamsters Infected with Leishmania infantum
por: Olías-Molero, Ana Isabel, et al.
Publicado: (2023)

The Photodynamic Antibacterial Effects of Silicon Phthalocyanine (Pc) 4
por: Dimaano, Matthew L., et al.
Publicado: (2015)

Clindamycin-resistant Streptococcus pneumoniae
por: Montagnani, Francesca, et al.
Publicado: (2007)

Interaction between tacrolimus and clindamycin
por: Jouret, François, et al.
Publicado: (2010)

Adjunctive clindamycin for cellulitis: a clinical trial comparing flucloxacillin with or without clindamycin for the treatment of limb cellulitis
por: Brindle, Richard, et al.
Publicado: (2017)

Pioneer colonizers: Bacteria that alter the chicken intestinal morphology and development of the microbiota
por: Lee, Margie D., et al.
Publicado: (2023)

The Inhibitory Effect of Clindamycin on Lactobacillus in vitro
por: Aroutcheva, Alla, et al.
Publicado: (2001)

Anaphylaxis to clindamycin following cutaneous exposure
por: Paradis, N., et al.
Publicado: (2020)

Pyodermatitis vegetans responding to rifampicin and clindamycin
por: Alfurayh, Nuha, et al.
Publicado: (2019)

Can Electronic Clinical Decision Support Systems Improve the Diagnosis of Urinary Tract Infections? A Systematic Review and Meta-Analysis
por: Hojat, Leila S, et al.
Publicado: (2022)

Randomized Clinical Trial of Intrapartum Clindamycin Cream for Reduction of Group B Streptococcal Maternal and Neonatal Colonization
por: Gibbs, R. S., et al.
Publicado: (1996)

Introduction of Colonic and Fecal Microbiota From an Adult Pig Differently Affects the Growth, Gut Health, Intestinal Microbiota and Blood Metabolome of Newborn Piglets
por: Qi, Renli, et al.
Publicado: (2021)

Changes in the Serum Metabolome of Patients Treated With Broad-Spectrum Antibiotics
por: Jaskiw, George E., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_fsm47e03mjus1q9sc3515pfpt5