No expression of porcine endogenous retrovirus after pig to monkey xenotransplantation

This study was performed to investigate the expression of two porcine endogenous retrovirus (PERV) elements, PERV gag and full-length conserved PERV, in blood cells collected periodically from organ-recipient monkeys that underwent pig to non-human primate xenotransplantation. The heart and kidney-r...

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Autores principales: Hwang, Seongsoo, Jung, Yi-Deun, Cho, Kahee, Ock, Sun-A, Oh, Keon-Bong, Kim, Heui-Soo, Yun, Ik-Jin, Ahn, Curie, Park, Jin-Ki, Im, Seoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Association for Laboratory Animal Science 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079837/
https://www.ncbi.nlm.nih.gov/pubmed/24999364
http://dx.doi.org/10.5625/lar.2014.30.2.90
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author Hwang, Seongsoo
Jung, Yi-Deun
Cho, Kahee
Ock, Sun-A
Oh, Keon-Bong
Kim, Heui-Soo
Yun, Ik-Jin
Ahn, Curie
Park, Jin-Ki
Im, Seoki
author_facet Hwang, Seongsoo
Jung, Yi-Deun
Cho, Kahee
Ock, Sun-A
Oh, Keon-Bong
Kim, Heui-Soo
Yun, Ik-Jin
Ahn, Curie
Park, Jin-Ki
Im, Seoki
author_sort Hwang, Seongsoo
collection PubMed
description This study was performed to investigate the expression of two porcine endogenous retrovirus (PERV) elements, PERV gag and full-length conserved PERV, in blood cells collected periodically from organ-recipient monkeys that underwent pig to non-human primate xenotransplantation. The heart and kidney-respectively acquired from α-1,3-galactosyltransferase knockout (GT-KO) pigs that survived for24 and 25 days-were xenografted into cynomolgus monkeys. The two PERV elements expressed in the xenografted GT-KO pig organs were not present in the blood cells of the recipient monkeys. In the present study, we deduced that PERVs are not transmitted during GT-KO pig to monkey xenotransplantation.
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spelling pubmed-40798372014-07-04 No expression of porcine endogenous retrovirus after pig to monkey xenotransplantation Hwang, Seongsoo Jung, Yi-Deun Cho, Kahee Ock, Sun-A Oh, Keon-Bong Kim, Heui-Soo Yun, Ik-Jin Ahn, Curie Park, Jin-Ki Im, Seoki Lab Anim Res Case Report This study was performed to investigate the expression of two porcine endogenous retrovirus (PERV) elements, PERV gag and full-length conserved PERV, in blood cells collected periodically from organ-recipient monkeys that underwent pig to non-human primate xenotransplantation. The heart and kidney-respectively acquired from α-1,3-galactosyltransferase knockout (GT-KO) pigs that survived for24 and 25 days-were xenografted into cynomolgus monkeys. The two PERV elements expressed in the xenografted GT-KO pig organs were not present in the blood cells of the recipient monkeys. In the present study, we deduced that PERVs are not transmitted during GT-KO pig to monkey xenotransplantation. Korean Association for Laboratory Animal Science 2014-06 2014-06-23 /pmc/articles/PMC4079837/ /pubmed/24999364 http://dx.doi.org/10.5625/lar.2014.30.2.90 Text en Copyright © 2014 Korean Association for Laboratory Animal Science http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Hwang, Seongsoo
Jung, Yi-Deun
Cho, Kahee
Ock, Sun-A
Oh, Keon-Bong
Kim, Heui-Soo
Yun, Ik-Jin
Ahn, Curie
Park, Jin-Ki
Im, Seoki
No expression of porcine endogenous retrovirus after pig to monkey xenotransplantation
title No expression of porcine endogenous retrovirus after pig to monkey xenotransplantation
title_full No expression of porcine endogenous retrovirus after pig to monkey xenotransplantation
title_fullStr No expression of porcine endogenous retrovirus after pig to monkey xenotransplantation
title_full_unstemmed No expression of porcine endogenous retrovirus after pig to monkey xenotransplantation
title_short No expression of porcine endogenous retrovirus after pig to monkey xenotransplantation
title_sort no expression of porcine endogenous retrovirus after pig to monkey xenotransplantation
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079837/
https://www.ncbi.nlm.nih.gov/pubmed/24999364
http://dx.doi.org/10.5625/lar.2014.30.2.90
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