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Can chemotherapy alone eliminate the transmission of soil transmitted helminths?

BACKGROUND: Amongst the world’s poorest populations, availability of anthelmintic treatments for the control of soil transmitted helminths (STH) by mass or targeted chemotherapy has increased dramatically in recent years. However, the design of community based treatment programmes to achieve the gre...

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Autores principales: Truscott, James E, Hollingsworth, T Déirdre, Brooker, Simon J, Anderson, Roy M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079919/
https://www.ncbi.nlm.nih.gov/pubmed/24916278
http://dx.doi.org/10.1186/1756-3305-7-266
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author Truscott, James E
Hollingsworth, T Déirdre
Brooker, Simon J
Anderson, Roy M
author_facet Truscott, James E
Hollingsworth, T Déirdre
Brooker, Simon J
Anderson, Roy M
author_sort Truscott, James E
collection PubMed
description BACKGROUND: Amongst the world’s poorest populations, availability of anthelmintic treatments for the control of soil transmitted helminths (STH) by mass or targeted chemotherapy has increased dramatically in recent years. However, the design of community based treatment programmes to achieve the greatest impact on transmission is still open to debate. Questions include: who should be treated, how often should they be treated, how long should treatment be continued for? METHODS: Simulation and analysis of a dynamic transmission model and novel data analyses suggest refinements of the World Health Organization guidelines for the community based treatment of STH. RESULTS: This analysis shows that treatment levels and frequency must be much higher, and the breadth of coverage across age classes broader than is typically the current practice, if transmission is to be interrupted by mass chemotherapy alone. CONCLUSIONS: When planning interventions to reduce transmission, rather than purely to reduce morbidity, current school-based interventions are unlikely to be enough to achieve the desired results.
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spelling pubmed-40799192014-07-03 Can chemotherapy alone eliminate the transmission of soil transmitted helminths? Truscott, James E Hollingsworth, T Déirdre Brooker, Simon J Anderson, Roy M Parasit Vectors Research BACKGROUND: Amongst the world’s poorest populations, availability of anthelmintic treatments for the control of soil transmitted helminths (STH) by mass or targeted chemotherapy has increased dramatically in recent years. However, the design of community based treatment programmes to achieve the greatest impact on transmission is still open to debate. Questions include: who should be treated, how often should they be treated, how long should treatment be continued for? METHODS: Simulation and analysis of a dynamic transmission model and novel data analyses suggest refinements of the World Health Organization guidelines for the community based treatment of STH. RESULTS: This analysis shows that treatment levels and frequency must be much higher, and the breadth of coverage across age classes broader than is typically the current practice, if transmission is to be interrupted by mass chemotherapy alone. CONCLUSIONS: When planning interventions to reduce transmission, rather than purely to reduce morbidity, current school-based interventions are unlikely to be enough to achieve the desired results. BioMed Central 2014-06-10 /pmc/articles/PMC4079919/ /pubmed/24916278 http://dx.doi.org/10.1186/1756-3305-7-266 Text en Copyright © 2014 Truscott et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Truscott, James E
Hollingsworth, T Déirdre
Brooker, Simon J
Anderson, Roy M
Can chemotherapy alone eliminate the transmission of soil transmitted helminths?
title Can chemotherapy alone eliminate the transmission of soil transmitted helminths?
title_full Can chemotherapy alone eliminate the transmission of soil transmitted helminths?
title_fullStr Can chemotherapy alone eliminate the transmission of soil transmitted helminths?
title_full_unstemmed Can chemotherapy alone eliminate the transmission of soil transmitted helminths?
title_short Can chemotherapy alone eliminate the transmission of soil transmitted helminths?
title_sort can chemotherapy alone eliminate the transmission of soil transmitted helminths?
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079919/
https://www.ncbi.nlm.nih.gov/pubmed/24916278
http://dx.doi.org/10.1186/1756-3305-7-266
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