Cargando…

Notch pathway inhibition controls myeloma bone disease in the murine MOPC315.BM model

Despite evidence that deregulated Notch signalling is a master regulator of multiple myeloma (MM) pathogenesis, its contribution to myeloma bone disease remains to be resolved. Notch promotes survival of human MM cells and triggers human osteoclast activity in vitro. Here, we show that inhibition of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schwarzer, R, Nickel, N, Godau, J, Willie, B M, Duda, G N, Cirovic, B, Leutz, A, Manz, R, Bogen, B, Dörken, B, Jundt, F
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080208/ https://www.ncbi.nlm.nih.gov/pubmed/24927406 http://dx.doi.org/10.1038/bcj.2014.37

Ejemplares similares

A Novel Mouse Model for Multiple Myeloma (MOPC315.BM) That Allows Noninvasive Spatiotemporal Detection of Osteolytic Disease
por: Hofgaard, Peter O., et al.
Publicado: (2012)

Eosinophils and Megakaryocytes Support the Early Growth of Murine MOPC315 Myeloma Cells in Their Bone Marrow Niches
por: Wong, David, et al.
Publicado: (2014)

Control of immunoglobulin secretion in the murine plasmacytoma line MOPC 315
Publicado: (1978)

Immunoregulation of murine myeloma in vitro. II. Suppression of MOPC- 315 immunoglobulin secretion and synthesis by idiotype-specific suppressor T cells
Publicado: (1982)

Overexpression of VEGF in the MOPC 315 Plasmacytoma Induces Tumor Immunity in Mice
por: Kim, Byung-Gyu, et al.
Publicado: (2022)

Targeting of beta-glucuronidase to lysosomes in mannose 6-phosphate receptor-deficient MOPC 315 cells
Publicado: (1984)

Enhancing effect of bromovinyldeoxyuridine on antitumour activity of 5-fluorouracil in mice bearing MOPC-315 plasmacytomas.
por: Ben-Efraim, S., et al.
Publicado: (1986)

Binding of antigen by immunocytes. II. Effect of specific Ig on antigen binding by MOPC 315 cells
Publicado: (1975)

BINDING OF ANTIGEN BY IMMUNOCYTES : I. EFFECT OF LIGAND VALENCE ON BINDING AFFINITY OF MOPC 315 CELLS FOR DNP CONJUGATES
por: Bystryn, Jean-Claude, et al.
Publicado: (1973)

Processing of MOPC 315 immunoglobulin A oligosaccharides: evidence for endoplasmic reticulum and trans Golgi alpha 1,2-mannosidase activity
Publicado: (1984)

Prevention of Bone Destruction by Mechanical Loading Is Not Enhanced by the Bruton’s Tyrosine Kinase Inhibitor CC-292 in Myeloma Bone Disease
por: Ziouti, Fani, et al.
Publicado: (2021)

MOPCS: next-generation nucleic acid molecular biosensor
por: Liu, Quan, et al.
Publicado: (2022)

An Early Myeloma Bone Disease Model in Skeletally Mature Mice as a Platform for Biomaterial Characterization of the Extracellular Matrix
por: Ziouti, Fani, et al.
Publicado: (2020)

Identification of NOTCH-driven matrisome-associated genes as prognostic indicators of multiple myeloma patient survival
por: Maichl, Daniela Simone, et al.
Publicado: (2023)

Reviewers BJCVS 31.5
Publicado: (2016)

Health Tract No. 315: Presentiments
Publicado: (1868)

Epigenetic silencing of long non-coding RNA BM742401 in multiple myeloma: impact on prognosis and myeloma dissemination
por: Li, Zhenhai, et al.
Publicado: (2020)

NOTCH Signaling Is Activated through Mechanical Strain in Human Bone Marrow-Derived Mesenchymal Stromal Cells
por: Ziouti, Fani, et al.
Publicado: (2019)

The Peroxisomal-CoA Synthetase MoPcs60 Is Important for Fatty Acid Metabolism and Infectious Growth of the Rice Blast Fungus
por: Zhang, Ting, et al.
Publicado: (2022)

T315I-mutated myeloid sarcoma
por: Zhang, Yumeng, et al.
Publicado: (2019)

Interaction of Destruxin A with Three Silkworm Proteins: BmCRT, BmDPP3, and BmPDIA5
por: Yin, Xuyu, et al.
Publicado: (2022)

Residue 315 regulates V3 exposure and V3 antibody recognition on HIV subtype B and C viruses
por: Manhas, S, et al.
Publicado: (2012)

GEM tracking system of the BM@N experiment
por: Baranov, D, et al.
Publicado: (2017)

Helper T cell recognition of the variable domains of a mouse myeloma protein (315). Effect of the major histocompatibility complex and domain conformation
Publicado: (1982)

Knockdown of BmTCP-1β Delays BmNPV Infection in vitro
por: Wang, Xue-yang, et al.
Publicado: (2019)

The multifunctional role of Notch signaling in multiple myeloma
por: Sabol, Hayley M., et al.
Publicado: (2021)

Triple GEM Tracking Detectors for the BM@N Experiment
por: Bazylev, S, et al.
Publicado: (2018)

Endogenous progesterone levels and frontotemporal dementia: modulation of TDP-43 and Tau levels in vitro and treatment of the A315T TARDBP mouse model
por: Dang, Theresa N. T., et al.
Publicado: (2013)

T helper cells recognize an idiotope located on peptide 88-114/117 of the light chain variable domain of an isologous myeloma protein (315)
Publicado: (1983)

The theory of everything: quantum and relativity is everywhere : a Fermat Universe
por: Schwarzer, Norbert
Publicado: (2020)

Regarding: ‘Epoetin β treatment in patients with cancer chemotherapy induced anaemia: the impact of initial haemoglobin and target haemoglobin levels on survival, tumour progression and thromboembolic events’
por: Schwarzer, G
Publicado: (2009)

USA: Wahlsieg der Demokraten
por: Schwarzer, Daniela
Publicado: (2020)

Cellular basis of regulation of expression of idiotype. II. Immunity to anti-MOPC-460 idiotype antibodies increases the level of anti- trinitrophenyl antibodies bearing 460 idiotypes
Publicado: (1979)

Pharmacological Properties of DOV 315,090, an ocinaplon metabolite
por: Berezhnoy, Dmytro, et al.
Publicado: (2008)

Mapping the Interaction Anatomy of BmP02 on Kv1.3 Channel
por: Wu, B., et al.
Publicado: (2016)

Discrepancies between the percentage of plasma cells in bone marrow aspiration and BM biopsy: Impact on the revised IMWG diagnostic criteria of multiple myeloma
por: Lee, N, et al.
Publicado: (2017)

BmREEPa Is a Novel Gene that Facilitates BmNPV Entry into Silkworm Cells
por: Dong, Xiao-long, et al.
Publicado: (2015)

C/EBP-Induced Transdifferentiation Reveals Granulocyte-Macrophage Precursor-like Plasticity of B Cells
por: Cirovic, Branko, et al.
Publicado: (2017)

P856: A SINGLE-CELL FUNCTIONAL PRECISION MEDICINE LANDSCAPE OF MULTIPLE MYELOMA
por: Kropivsek, K., et al.
Publicado: (2022)

The biology of malignant breast tumors has an impact on the presentation in ultrasound: an analysis of 315 cases
por: Wojcinski, S, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_ujm5g73eof6nmq1p8614dscr5a