Cargando…

Reversal of autism-like behaviors and metabolism in adult mice with single-dose antipurinergic therapy

Autism spectrum disorders (ASDs) now affect 1–2% of the children born in the United States. Hundreds of genetic, metabolic and environmental factors are known to increase the risk of ASD. Similar factors are known to influence the risk of schizophrenia and bipolar disorder; however, a unifying mecha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Naviaux, J C, Schuchbauer, M A, Li, K, Wang, L, Risbrough, V B, Powell, S B, Naviaux, R K
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080315/ https://www.ncbi.nlm.nih.gov/pubmed/24937094 http://dx.doi.org/10.1038/tp.2014.33

Ejemplares similares

Antipurinergic Therapy Corrects the Autism-Like Features in the Poly(IC) Mouse Model
por: Naviaux, Robert K., et al.
Publicado: (2013)

Antipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model
por: Naviaux, Jane C, et al.
Publicado: (2015)

Metabolic and behavioral features of acute hyperpurinergia and the maternal immune activation mouse model of autism spectrum disorder
por: Zolkipli-Cunningham, Zarazuela, et al.
Publicado: (2021)

A robust, single-injection method for targeted, broad-spectrum plasma metabolomics
por: Li, Kefeng, et al.
Publicado: (2017)

Improved Dried Blood Spot-Based Metabolomics: A Targeted, Broad-Spectrum, Single-Injection Method
por: Li, Kefeng, et al.
Publicado: (2020)

Incomplete Healing as a Cause of Aging: The Role of Mitochondria and the Cell Danger Response
por: Naviaux, Robert K.
Publicado: (2019)

Metabolic features of Gulf War illness
por: Naviaux, Robert K., et al.
Publicado: (2019)

Low‐dose suramin in autism spectrum disorder: a small, phase I/II, randomized clinical trial
por: Naviaux, Robert K., et al.
Publicado: (2017)

Comprehensive Nutritional and Dietary Intervention for Autism Spectrum Disorder—A Randomized, Controlled 12-Month Trial
por: Adams, James B., et al.
Publicado: (2018)

Englerin A induces an acute inflammatory response and reveals lipid metabolism and ER stress as targetable vulnerabilities in renal cell carcinoma
por: Batova, Ayse, et al.
Publicado: (2017)

Metabolic features of recurrent major depressive disorder in remission, and the risk of future recurrence
por: Mocking, Roel J. T., et al.
Publicado: (2021)

Correction to: Metabolic features of recurrent major depressive disorder in remission, and the risk of future recurrence
por: Mocking, Roel J. T., et al.
Publicado: (2021)

Reply to “Comment on Comprehensive Nutritional and Dietary Intervention for Autism Spectrum Disorder—A Randomized, Controlled 12-Month Trial, Nutrients 2018, 10, 369”
por: Adams, James B., et al.
Publicado: (2019)

Metabolomic and exposomic biomarkers of risk of future neurodevelopmental delay in human milk
por: Li, Kefeng, et al.
Publicado: (2022)

Aspects médico-psychologiques relatifs à l’épidémie de coronavirus (Covid-19) : l’apport de la théorie de la détection du signal et du concept de lieu de contrôle
por: Naviaux, Anne-Frédérique, et al.
Publicado: (2020)

La pandémie du Covid-19 : surdosage médiatique, craintes et bientôt antonomase ? Une pandémie exposant deux
por: Naviaux, Anne-Frédérique, et al.
Publicado: (2020)

Zinc Water Prevents Autism-Like Behaviors in the BTBR Mice
por: Zhang, Li, et al.
Publicado: (2023)

A Mutation in the Mitochondrial Aspartate/Glutamate Carrier Leads to a More Oxidizing Intramitochondrial Environment and an Inflammatory Myopathy in Dutch Shepherd Dogs
por: Shelton, G. Diane, et al.
Publicado: (2019)

Metabolomic disorders: confirmed presence of potentially treatable abnormalities in patients with treatment refractory depression and suicidal behavior
por: Pan, Lisa A., et al.
Publicado: (2023)

Autism-like behaviors in male mice with a Pcdh19 deletion
por: Lim, Jisoo, et al.
Publicado: (2019)

Prenatal and early-life diesel exhaust exposure causes autism-like behavioral changes in mice
por: Chang, Yu-Chi, et al.
Publicado: (2018)

Rev1 deficiency induces a metabolic shift in MEFs that can be manipulated by the NAD(+) precursor nicotinamide riboside
por: Anugula, Sharath, et al.
Publicado: (2023)

SARM1 deletion in parvalbumin neurons is associated with autism-like behaviors in mice
por: Xiang, Ludan, et al.
Publicado: (2022)

WDR62-deficiency Causes Autism-like Behaviors Independent of Microcephaly in Mice
por: Xu, Dan, et al.
Publicado: (2022)

Valproate reverses mania-like behaviors in mice via preferential targeting of HDAC2
por: Logan, Ryan W., et al.
Publicado: (2020)

Translational control and autism-like behaviors
por: Gkogkas, Christos G., et al.
Publicado: (2013)

Reversal of memory and autism-related phenotypes in Tsc2 ( +/− ) mice via inhibition of Nlgn1
por: Chalkiadaki, Kleanthi, et al.
Publicado: (2023)

Pre- and Postnatal Exposure to Low Dose Glufosinate Ammonium Induces Autism-Like Phenotypes in Mice
por: Laugeray, Anthony, et al.
Publicado: (2014)

Chronic presence of blood circulating anti-NMDAR1 autoantibodies impairs cognitive function in mice
por: Yue, William, et al.
Publicado: (2021)

Maternal immune activation and strain specific interactions in the development of autism-like behaviors in mice
por: Schwartzer, J J, et al.
Publicado: (2013)

Gender Dependent Evaluation of Autism like Behavior in Mice Exposed to Prenatal Zinc Deficiency
por: Grabrucker, Stefanie, et al.
Publicado: (2016)

Autism-Like Behavioral Phenotypes in Mice Treated with Systemic N-Methyl-D-Aspartate
por: Adil, Keremkleroo Jym, et al.
Publicado: (2022)

Impaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice
por: Wang, Qian, et al.
Publicado: (2021)

Restoration of Sp4 in Forebrain GABAergic Neurons Rescues Hypersensitivity to Ketamine in Sp4 Hypomorphic Mice
por: Higa, Kerin K., et al.
Publicado: (2015)

P-cresol Alters Brain Dopamine Metabolism and Exacerbates Autism-Like Behaviors in the BTBR Mouse
por: Pascucci, Tiziana, et al.
Publicado: (2020)

The Drosophila Gene Sulfateless Modulates Autism-Like Behaviors
por: Hope, Kevin A., et al.
Publicado: (2019)

Identification of Maltase Glucoamylase as a Biomarker of Acute Kidney Injury in Patients with Cirrhosis
por: Awdishu, Linda, et al.
Publicado: (2019)

Pogz deficiency leads to transcription dysregulation and impaired cerebellar activity underlying autism-like behavior in mice
por: Suliman-Lavie, Reut, et al.
Publicado: (2020)

Altered gut microbiome and autism like behavior are associated with parental high salt diet in male mice
por: Afroz, Kazi Farhana, et al.
Publicado: (2021)

Altered meningeal immunity contributing to the autism-like behavior of BTBR T(+)Itpr3(tf)/J mice
por: Uddin, Mohammad Nizam, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ea3ikunmdambdmbg6urvjk3ap8