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Predictors and Variability of Repeat Measurements of Urinary Phenols and Parabens in a Cohort of Shanghai Women and Men

Background: Exposure to certain phenols is ubiquitous because of their use in many consumer and personal care products. However, predictors of exposure have not been well characterized in most populations. Objectives: We sought to identify predictors of exposure and to assess the reproducibility of...

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Autores principales: Engel, Lawrence S., Buckley, Jessie P., Yang, Gong, Liao, Linda M., Satagopan, Jaya, Calafat, Antonia M., Matthews, Charles E., Cai, Qiuyin, Ji, Bu-Tian, Cai, Hui, Engel, Stephanie M., Wolff, Mary S., Rothman, Nathaniel, Zheng, Wei, Xiang, Yong-Bing, Shu, Xiao-Ou, Gao, Yu-Tang, Chow, Wong-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: NLM-Export 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080538/
https://www.ncbi.nlm.nih.gov/pubmed/24659570
http://dx.doi.org/10.1289/ehp.1306830
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author Engel, Lawrence S.
Buckley, Jessie P.
Yang, Gong
Liao, Linda M.
Satagopan, Jaya
Calafat, Antonia M.
Matthews, Charles E.
Cai, Qiuyin
Ji, Bu-Tian
Cai, Hui
Engel, Stephanie M.
Wolff, Mary S.
Rothman, Nathaniel
Zheng, Wei
Xiang, Yong-Bing
Shu, Xiao-Ou
Gao, Yu-Tang
Chow, Wong-Ho
author_facet Engel, Lawrence S.
Buckley, Jessie P.
Yang, Gong
Liao, Linda M.
Satagopan, Jaya
Calafat, Antonia M.
Matthews, Charles E.
Cai, Qiuyin
Ji, Bu-Tian
Cai, Hui
Engel, Stephanie M.
Wolff, Mary S.
Rothman, Nathaniel
Zheng, Wei
Xiang, Yong-Bing
Shu, Xiao-Ou
Gao, Yu-Tang
Chow, Wong-Ho
author_sort Engel, Lawrence S.
collection PubMed
description Background: Exposure to certain phenols is ubiquitous because of their use in many consumer and personal care products. However, predictors of exposure have not been well characterized in most populations. Objectives: We sought to identify predictors of exposure and to assess the reproducibility of phenol concentrations across serial spot urine samples among Chinese adults. Methods: We measured 2,4-dichlorophenol, 2,5-dichlorophenol, butyl paraben, methyl paraben, propyl paraben, benzophenone-3, bisphenol A, and triclosan in urine collected during 1997–2006 from 50 participants of the Shanghai Women’s Health Study cohort and during 2002–2006 from 50 participants of the Shanghai Men’s Health Study cohort. We investigated predictors of concentrations using the Satterthwaite t-test, and assessed reproducibility among serial samples using intraclass correlation coefficients (ICCs) and Spearman correlation coefficients (SCCs). Results: Creatinine-corrected phenol concentrations were generally higher among women than men. Participants who had taken medicine within the previous 24 hr had higher concentrations of propyl paraben. Cigarette smoking was associated with lower concentrations of propyl and methyl parabens among men. Bottled water consumption was associated with higher bisphenol A, 2,4-dichlorophenol, and 2,5-dichlorophenol concentrations among women. Among men, reproducibility across serial samples was moderate for 2,4-dichlorophenol and 2,5-dichlorophenol (ICC = 0.54–0.60, SCC = 0.43–0.56), but lower for other analytes (ICC = 0.20–0.29). Reproducibility among women was low (ICC = 0.13–0.39), but increased when restricted to morning-only urine samples. Conclusions: Among these 100 Shanghai residents, urinary phenol concentrations varied by sex, smoking, and consumption of bottled water. Our results suggest that a single urine sample may be adequate for ranking exposure to the precursors of 2,4-dichlorophenol and 2,5-dichlorophenol among men and, under certain circumstances, among women. Citation: Engel LS, Buckley JP, Yang G, Liao LM, Satagopan J, Calafat AM, Matthews CE, Cai Q, Ji BT, Cai H, Engel SM, Wolff MS, Rothman N, Zheng W, Xiang YB, Shu XO, Gao YT, Chow WH. 2014. Predictors and variability of repeat measurements of urinary phenols and parabens in a cohort of Shanghai women and men. Environ Health Perspect 122:733–740; http://dx.doi.org/10.1289/ehp.1306830
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spelling pubmed-40805382014-07-11 Predictors and Variability of Repeat Measurements of Urinary Phenols and Parabens in a Cohort of Shanghai Women and Men Engel, Lawrence S. Buckley, Jessie P. Yang, Gong Liao, Linda M. Satagopan, Jaya Calafat, Antonia M. Matthews, Charles E. Cai, Qiuyin Ji, Bu-Tian Cai, Hui Engel, Stephanie M. Wolff, Mary S. Rothman, Nathaniel Zheng, Wei Xiang, Yong-Bing Shu, Xiao-Ou Gao, Yu-Tang Chow, Wong-Ho Environ Health Perspect Research Background: Exposure to certain phenols is ubiquitous because of their use in many consumer and personal care products. However, predictors of exposure have not been well characterized in most populations. Objectives: We sought to identify predictors of exposure and to assess the reproducibility of phenol concentrations across serial spot urine samples among Chinese adults. Methods: We measured 2,4-dichlorophenol, 2,5-dichlorophenol, butyl paraben, methyl paraben, propyl paraben, benzophenone-3, bisphenol A, and triclosan in urine collected during 1997–2006 from 50 participants of the Shanghai Women’s Health Study cohort and during 2002–2006 from 50 participants of the Shanghai Men’s Health Study cohort. We investigated predictors of concentrations using the Satterthwaite t-test, and assessed reproducibility among serial samples using intraclass correlation coefficients (ICCs) and Spearman correlation coefficients (SCCs). Results: Creatinine-corrected phenol concentrations were generally higher among women than men. Participants who had taken medicine within the previous 24 hr had higher concentrations of propyl paraben. Cigarette smoking was associated with lower concentrations of propyl and methyl parabens among men. Bottled water consumption was associated with higher bisphenol A, 2,4-dichlorophenol, and 2,5-dichlorophenol concentrations among women. Among men, reproducibility across serial samples was moderate for 2,4-dichlorophenol and 2,5-dichlorophenol (ICC = 0.54–0.60, SCC = 0.43–0.56), but lower for other analytes (ICC = 0.20–0.29). Reproducibility among women was low (ICC = 0.13–0.39), but increased when restricted to morning-only urine samples. Conclusions: Among these 100 Shanghai residents, urinary phenol concentrations varied by sex, smoking, and consumption of bottled water. Our results suggest that a single urine sample may be adequate for ranking exposure to the precursors of 2,4-dichlorophenol and 2,5-dichlorophenol among men and, under certain circumstances, among women. Citation: Engel LS, Buckley JP, Yang G, Liao LM, Satagopan J, Calafat AM, Matthews CE, Cai Q, Ji BT, Cai H, Engel SM, Wolff MS, Rothman N, Zheng W, Xiang YB, Shu XO, Gao YT, Chow WH. 2014. Predictors and variability of repeat measurements of urinary phenols and parabens in a cohort of Shanghai women and men. Environ Health Perspect 122:733–740; http://dx.doi.org/10.1289/ehp.1306830 NLM-Export 2014-03-21 2014-07 /pmc/articles/PMC4080538/ /pubmed/24659570 http://dx.doi.org/10.1289/ehp.1306830 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, “Reproduced with permission from Environmental Health Perspectives”); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.
spellingShingle Research
Engel, Lawrence S.
Buckley, Jessie P.
Yang, Gong
Liao, Linda M.
Satagopan, Jaya
Calafat, Antonia M.
Matthews, Charles E.
Cai, Qiuyin
Ji, Bu-Tian
Cai, Hui
Engel, Stephanie M.
Wolff, Mary S.
Rothman, Nathaniel
Zheng, Wei
Xiang, Yong-Bing
Shu, Xiao-Ou
Gao, Yu-Tang
Chow, Wong-Ho
Predictors and Variability of Repeat Measurements of Urinary Phenols and Parabens in a Cohort of Shanghai Women and Men
title Predictors and Variability of Repeat Measurements of Urinary Phenols and Parabens in a Cohort of Shanghai Women and Men
title_full Predictors and Variability of Repeat Measurements of Urinary Phenols and Parabens in a Cohort of Shanghai Women and Men
title_fullStr Predictors and Variability of Repeat Measurements of Urinary Phenols and Parabens in a Cohort of Shanghai Women and Men
title_full_unstemmed Predictors and Variability of Repeat Measurements of Urinary Phenols and Parabens in a Cohort of Shanghai Women and Men
title_short Predictors and Variability of Repeat Measurements of Urinary Phenols and Parabens in a Cohort of Shanghai Women and Men
title_sort predictors and variability of repeat measurements of urinary phenols and parabens in a cohort of shanghai women and men
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080538/
https://www.ncbi.nlm.nih.gov/pubmed/24659570
http://dx.doi.org/10.1289/ehp.1306830
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