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Relative Undernourishment and Food Insecurity Associations with Plasmodium falciparum Among Batwa Pygmies in Uganda: Evidence from a Cross-Sectional Survey

Although malnutrition and malaria co-occur among individuals and populations globally, effects of nutritional status on risk for parasitemia and clinical illness remain poorly understood. We investigated associations between Plasmodium falciparum infection, nutrition, and food security in a cross-se...

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Autores principales: Lewnard, Joseph A., Berrang-Ford, Lea, Lwasa, Shuaib, Namanya, Didacus Bambaiha, Patterson, Kaitlin A., Donnelly, Blánaid, Kulkarni, Manisha A., Harper, Sherilee L., Ogden, Nicholas H., Carcamo, Cesar P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080566/
https://www.ncbi.nlm.nih.gov/pubmed/24821844
http://dx.doi.org/10.4269/ajtmh.13-0422
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author Lewnard, Joseph A.
Berrang-Ford, Lea
Lwasa, Shuaib
Namanya, Didacus Bambaiha
Patterson, Kaitlin A.
Donnelly, Blánaid
Kulkarni, Manisha A.
Harper, Sherilee L.
Ogden, Nicholas H.
Carcamo, Cesar P.
author_facet Lewnard, Joseph A.
Berrang-Ford, Lea
Lwasa, Shuaib
Namanya, Didacus Bambaiha
Patterson, Kaitlin A.
Donnelly, Blánaid
Kulkarni, Manisha A.
Harper, Sherilee L.
Ogden, Nicholas H.
Carcamo, Cesar P.
author_sort Lewnard, Joseph A.
collection PubMed
description Although malnutrition and malaria co-occur among individuals and populations globally, effects of nutritional status on risk for parasitemia and clinical illness remain poorly understood. We investigated associations between Plasmodium falciparum infection, nutrition, and food security in a cross-sectional survey of 365 Batwa pygmies in Kanungu District, Uganda in January of 2013. We identified 4.1% parasite prevalence among individuals over 5 years old. Severe food insecurity was associated with increased risk for positive rapid immunochromatographic test outcome (adjusted relative risk [ARR] = 13.09; 95% confidence interval [95% CI] = 2.23–76.79). High age/sex-adjusted mid-upper arm circumference was associated with decreased risk for positive test among individuals who were not severely food-insecure (ARR = 0.37; 95% CI = 0.19–0.69). Within Batwa pygmy communities, where malnutrition and food insecurity are common, individuals who are particularly undernourished or severely food-insecure may have elevated risk for P. falciparum parasitemia. This finding may motivate integrated control of malaria and malnutrition in low-transmission settings.
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spelling pubmed-40805662014-07-11 Relative Undernourishment and Food Insecurity Associations with Plasmodium falciparum Among Batwa Pygmies in Uganda: Evidence from a Cross-Sectional Survey Lewnard, Joseph A. Berrang-Ford, Lea Lwasa, Shuaib Namanya, Didacus Bambaiha Patterson, Kaitlin A. Donnelly, Blánaid Kulkarni, Manisha A. Harper, Sherilee L. Ogden, Nicholas H. Carcamo, Cesar P. Am J Trop Med Hyg Articles Although malnutrition and malaria co-occur among individuals and populations globally, effects of nutritional status on risk for parasitemia and clinical illness remain poorly understood. We investigated associations between Plasmodium falciparum infection, nutrition, and food security in a cross-sectional survey of 365 Batwa pygmies in Kanungu District, Uganda in January of 2013. We identified 4.1% parasite prevalence among individuals over 5 years old. Severe food insecurity was associated with increased risk for positive rapid immunochromatographic test outcome (adjusted relative risk [ARR] = 13.09; 95% confidence interval [95% CI] = 2.23–76.79). High age/sex-adjusted mid-upper arm circumference was associated with decreased risk for positive test among individuals who were not severely food-insecure (ARR = 0.37; 95% CI = 0.19–0.69). Within Batwa pygmy communities, where malnutrition and food insecurity are common, individuals who are particularly undernourished or severely food-insecure may have elevated risk for P. falciparum parasitemia. This finding may motivate integrated control of malaria and malnutrition in low-transmission settings. The American Society of Tropical Medicine and Hygiene 2014-07-02 /pmc/articles/PMC4080566/ /pubmed/24821844 http://dx.doi.org/10.4269/ajtmh.13-0422 Text en ©The American Society of Tropical Medicine and Hygiene This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Articles
Lewnard, Joseph A.
Berrang-Ford, Lea
Lwasa, Shuaib
Namanya, Didacus Bambaiha
Patterson, Kaitlin A.
Donnelly, Blánaid
Kulkarni, Manisha A.
Harper, Sherilee L.
Ogden, Nicholas H.
Carcamo, Cesar P.
Relative Undernourishment and Food Insecurity Associations with Plasmodium falciparum Among Batwa Pygmies in Uganda: Evidence from a Cross-Sectional Survey
title Relative Undernourishment and Food Insecurity Associations with Plasmodium falciparum Among Batwa Pygmies in Uganda: Evidence from a Cross-Sectional Survey
title_full Relative Undernourishment and Food Insecurity Associations with Plasmodium falciparum Among Batwa Pygmies in Uganda: Evidence from a Cross-Sectional Survey
title_fullStr Relative Undernourishment and Food Insecurity Associations with Plasmodium falciparum Among Batwa Pygmies in Uganda: Evidence from a Cross-Sectional Survey
title_full_unstemmed Relative Undernourishment and Food Insecurity Associations with Plasmodium falciparum Among Batwa Pygmies in Uganda: Evidence from a Cross-Sectional Survey
title_short Relative Undernourishment and Food Insecurity Associations with Plasmodium falciparum Among Batwa Pygmies in Uganda: Evidence from a Cross-Sectional Survey
title_sort relative undernourishment and food insecurity associations with plasmodium falciparum among batwa pygmies in uganda: evidence from a cross-sectional survey
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080566/
https://www.ncbi.nlm.nih.gov/pubmed/24821844
http://dx.doi.org/10.4269/ajtmh.13-0422
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