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Posterior reversible encephalopathy syndrome in pediatric acute leukemia: Case series and literature review

Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic state coupled with a unique radio imaging appearance. We describe this rare, mostly reversible condition in five cases undergoing similar treatment under preset protocol (MCP-841) for acute lymphoblastic leukemia (ALL) at our centre...

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Detalles Bibliográficos
Autores principales: Appachu, M. Sandhya, Purohit, Samit, Lakshmaiah, K. C., Kumari, B.S. Aruna, Appaji, L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080669/
https://www.ncbi.nlm.nih.gov/pubmed/25006290
http://dx.doi.org/10.4103/0971-5851.133727
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author Appachu, M. Sandhya
Purohit, Samit
Lakshmaiah, K. C.
Kumari, B.S. Aruna
Appaji, L.
author_facet Appachu, M. Sandhya
Purohit, Samit
Lakshmaiah, K. C.
Kumari, B.S. Aruna
Appaji, L.
author_sort Appachu, M. Sandhya
collection PubMed
description Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic state coupled with a unique radio imaging appearance. We describe this rare, mostly reversible condition in five cases undergoing similar treatment under preset protocol (MCP-841) for acute lymphoblastic leukemia (ALL) at our centre. Hypertension is a well-known adverse effect of high-dose corticosteroid therapy primarily mediated by its effects on the mineralocorticoid receptor especially in pediatric population and we hypothesize that this may be the etiology of PRES in two of these patients.
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spelling pubmed-40806692014-07-08 Posterior reversible encephalopathy syndrome in pediatric acute leukemia: Case series and literature review Appachu, M. Sandhya Purohit, Samit Lakshmaiah, K. C. Kumari, B.S. Aruna Appaji, L. Indian J Med Paediatr Oncol Case Report Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic state coupled with a unique radio imaging appearance. We describe this rare, mostly reversible condition in five cases undergoing similar treatment under preset protocol (MCP-841) for acute lymphoblastic leukemia (ALL) at our centre. Hypertension is a well-known adverse effect of high-dose corticosteroid therapy primarily mediated by its effects on the mineralocorticoid receptor especially in pediatric population and we hypothesize that this may be the etiology of PRES in two of these patients. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4080669/ /pubmed/25006290 http://dx.doi.org/10.4103/0971-5851.133727 Text en Copyright: © Indian Journal of Medical and Paediatric Oncology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Appachu, M. Sandhya
Purohit, Samit
Lakshmaiah, K. C.
Kumari, B.S. Aruna
Appaji, L.
Posterior reversible encephalopathy syndrome in pediatric acute leukemia: Case series and literature review
title Posterior reversible encephalopathy syndrome in pediatric acute leukemia: Case series and literature review
title_full Posterior reversible encephalopathy syndrome in pediatric acute leukemia: Case series and literature review
title_fullStr Posterior reversible encephalopathy syndrome in pediatric acute leukemia: Case series and literature review
title_full_unstemmed Posterior reversible encephalopathy syndrome in pediatric acute leukemia: Case series and literature review
title_short Posterior reversible encephalopathy syndrome in pediatric acute leukemia: Case series and literature review
title_sort posterior reversible encephalopathy syndrome in pediatric acute leukemia: case series and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080669/
https://www.ncbi.nlm.nih.gov/pubmed/25006290
http://dx.doi.org/10.4103/0971-5851.133727
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