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Posterior reversible encephalopathy syndrome in pediatric acute leukemia: Case series and literature review
Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic state coupled with a unique radio imaging appearance. We describe this rare, mostly reversible condition in five cases undergoing similar treatment under preset protocol (MCP-841) for acute lymphoblastic leukemia (ALL) at our centre...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080669/ https://www.ncbi.nlm.nih.gov/pubmed/25006290 http://dx.doi.org/10.4103/0971-5851.133727 |
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author | Appachu, M. Sandhya Purohit, Samit Lakshmaiah, K. C. Kumari, B.S. Aruna Appaji, L. |
author_facet | Appachu, M. Sandhya Purohit, Samit Lakshmaiah, K. C. Kumari, B.S. Aruna Appaji, L. |
author_sort | Appachu, M. Sandhya |
collection | PubMed |
description | Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic state coupled with a unique radio imaging appearance. We describe this rare, mostly reversible condition in five cases undergoing similar treatment under preset protocol (MCP-841) for acute lymphoblastic leukemia (ALL) at our centre. Hypertension is a well-known adverse effect of high-dose corticosteroid therapy primarily mediated by its effects on the mineralocorticoid receptor especially in pediatric population and we hypothesize that this may be the etiology of PRES in two of these patients. |
format | Online Article Text |
id | pubmed-4080669 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-40806692014-07-08 Posterior reversible encephalopathy syndrome in pediatric acute leukemia: Case series and literature review Appachu, M. Sandhya Purohit, Samit Lakshmaiah, K. C. Kumari, B.S. Aruna Appaji, L. Indian J Med Paediatr Oncol Case Report Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic state coupled with a unique radio imaging appearance. We describe this rare, mostly reversible condition in five cases undergoing similar treatment under preset protocol (MCP-841) for acute lymphoblastic leukemia (ALL) at our centre. Hypertension is a well-known adverse effect of high-dose corticosteroid therapy primarily mediated by its effects on the mineralocorticoid receptor especially in pediatric population and we hypothesize that this may be the etiology of PRES in two of these patients. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4080669/ /pubmed/25006290 http://dx.doi.org/10.4103/0971-5851.133727 Text en Copyright: © Indian Journal of Medical and Paediatric Oncology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Appachu, M. Sandhya Purohit, Samit Lakshmaiah, K. C. Kumari, B.S. Aruna Appaji, L. Posterior reversible encephalopathy syndrome in pediatric acute leukemia: Case series and literature review |
title | Posterior reversible encephalopathy syndrome in pediatric acute leukemia: Case series and literature review |
title_full | Posterior reversible encephalopathy syndrome in pediatric acute leukemia: Case series and literature review |
title_fullStr | Posterior reversible encephalopathy syndrome in pediatric acute leukemia: Case series and literature review |
title_full_unstemmed | Posterior reversible encephalopathy syndrome in pediatric acute leukemia: Case series and literature review |
title_short | Posterior reversible encephalopathy syndrome in pediatric acute leukemia: Case series and literature review |
title_sort | posterior reversible encephalopathy syndrome in pediatric acute leukemia: case series and literature review |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080669/ https://www.ncbi.nlm.nih.gov/pubmed/25006290 http://dx.doi.org/10.4103/0971-5851.133727 |
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