C-reactive protein is essential for innate resistance to pneumococcal infection

No deficiency of human C-reactive protein (CRP), or even structural polymorphism of the protein, has yet been reported so its physiological role is not known. Here we show for the first time that CRP-deficient mice are remarkably susceptible to Streptococcus pneumoniae infection and are protected by...

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Detalles Bibliográficos
Autores principales: Paul Simons, J, Loeffler, Jutta M, Al-Shawi, Raya, Ellmerich, Stephan, Hutchinson, Winston L, Tennent, Glenys A, Petrie, Aviva, Raynes, John G, de Souza, J Brian, Lawrence, Rachel A, Read, Kevin D, Pepys, Mark B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Science Inc 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080957/
https://www.ncbi.nlm.nih.gov/pubmed/24673624
http://dx.doi.org/10.1111/imm.12266

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