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Predictors of fatality in pandemic influenza A (H1N1) virus infection among adults

BACKGROUND: The fatality attributed to pandemic influenza A H1N1 was not clear in the literature. We described the predictors for fatality related to pandemic influenza A H1N1 infection among hospitalized adult patients. METHODS: This is a multicenter study performed during the pandemic influenza A...

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Autores principales: Ergönül, Önder, Alan, Servet, Ak, Öznur, Sargın, Fatman, Kantürk, Arzu, Gündüz, Alper, Engin, Derya, Öncül, Oral, Balkan, Ilker Inanc, Ceylan, Bahadir, Benzonana, Nur, Yazıcı, Saadet, Şimşek, Funda, Uzun, Nuray, İnan, Asuman, Gulhan, Eren, Ciblak, Meral, Midilli, Kenan, Ozyurt, Mustafa, Badur, Selim, Gencer, Serap, Nazlıcan, Ozcan, Özer, Serdar, Özgüneş, Nail, Yıldırmak, Taner, Aslan, Turan, Göktaş, Pasa, Saltoğlu, Nese, Fincancı, Muzaffer, Dokucu, Ali Ihsan, Eraksoy, Haluk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080987/
https://www.ncbi.nlm.nih.gov/pubmed/24916566
http://dx.doi.org/10.1186/1471-2334-14-317
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author Ergönül, Önder
Alan, Servet
Ak, Öznur
Sargın, Fatman
Kantürk, Arzu
Gündüz, Alper
Engin, Derya
Öncül, Oral
Balkan, Ilker Inanc
Ceylan, Bahadir
Benzonana, Nur
Yazıcı, Saadet
Şimşek, Funda
Uzun, Nuray
İnan, Asuman
Gulhan, Eren
Ciblak, Meral
Midilli, Kenan
Ozyurt, Mustafa
Badur, Selim
Gencer, Serap
Nazlıcan, Ozcan
Özer, Serdar
Özgüneş, Nail
Yıldırmak, Taner
Aslan, Turan
Göktaş, Pasa
Saltoğlu, Nese
Fincancı, Muzaffer
Dokucu, Ali Ihsan
Eraksoy, Haluk
author_facet Ergönül, Önder
Alan, Servet
Ak, Öznur
Sargın, Fatman
Kantürk, Arzu
Gündüz, Alper
Engin, Derya
Öncül, Oral
Balkan, Ilker Inanc
Ceylan, Bahadir
Benzonana, Nur
Yazıcı, Saadet
Şimşek, Funda
Uzun, Nuray
İnan, Asuman
Gulhan, Eren
Ciblak, Meral
Midilli, Kenan
Ozyurt, Mustafa
Badur, Selim
Gencer, Serap
Nazlıcan, Ozcan
Özer, Serdar
Özgüneş, Nail
Yıldırmak, Taner
Aslan, Turan
Göktaş, Pasa
Saltoğlu, Nese
Fincancı, Muzaffer
Dokucu, Ali Ihsan
Eraksoy, Haluk
author_sort Ergönül, Önder
collection PubMed
description BACKGROUND: The fatality attributed to pandemic influenza A H1N1 was not clear in the literature. We described the predictors for fatality related to pandemic influenza A H1N1 infection among hospitalized adult patients. METHODS: This is a multicenter study performed during the pandemic influenza A H1N1 [A(H1N1)pdm09] outbreak which occurred in 2009 and 2010. Analysis was performed among laboratory confirmed patients. Multivariate analysis was performed for the predictors of fatality. RESULTS: In the second wave of the pandemic, 848 adult patients were hospitalized because of suspected influenza, 45 out of 848 (5.3%) died, with 75% of fatalities occurring within the first 2 weeks of hospitalization. Among the 241 laboratory confirmed A(H1N1)pdm09 patients, the case fatality rate was 9%. In a multivariate logistic regression model that was performed for the fatalities within 14 days after admission, early use of neuraminidase inhibitors was found to be protective (Odds ratio: 0.17, confidence interval: 0.03-0.77, p = 0.022), nosocomial infections (OR: 5.7, CI: 1.84-18, p = 0.013), presence of malignant disease (OR: 3.8, CI: 0.66-22.01, p = 0.133) significantly increased the likelihood of fatality. CONCLUSIONS: Early detection of the infection, allowing opportunity for the early use of neuraminidase inhibitors, was found to be important for prevention of fatality. Nosocomial bacterial infections and underlying malignant diseases increased the rate of fatality.
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spelling pubmed-40809872014-07-04 Predictors of fatality in pandemic influenza A (H1N1) virus infection among adults Ergönül, Önder Alan, Servet Ak, Öznur Sargın, Fatman Kantürk, Arzu Gündüz, Alper Engin, Derya Öncül, Oral Balkan, Ilker Inanc Ceylan, Bahadir Benzonana, Nur Yazıcı, Saadet Şimşek, Funda Uzun, Nuray İnan, Asuman Gulhan, Eren Ciblak, Meral Midilli, Kenan Ozyurt, Mustafa Badur, Selim Gencer, Serap Nazlıcan, Ozcan Özer, Serdar Özgüneş, Nail Yıldırmak, Taner Aslan, Turan Göktaş, Pasa Saltoğlu, Nese Fincancı, Muzaffer Dokucu, Ali Ihsan Eraksoy, Haluk BMC Infect Dis Research Article BACKGROUND: The fatality attributed to pandemic influenza A H1N1 was not clear in the literature. We described the predictors for fatality related to pandemic influenza A H1N1 infection among hospitalized adult patients. METHODS: This is a multicenter study performed during the pandemic influenza A H1N1 [A(H1N1)pdm09] outbreak which occurred in 2009 and 2010. Analysis was performed among laboratory confirmed patients. Multivariate analysis was performed for the predictors of fatality. RESULTS: In the second wave of the pandemic, 848 adult patients were hospitalized because of suspected influenza, 45 out of 848 (5.3%) died, with 75% of fatalities occurring within the first 2 weeks of hospitalization. Among the 241 laboratory confirmed A(H1N1)pdm09 patients, the case fatality rate was 9%. In a multivariate logistic regression model that was performed for the fatalities within 14 days after admission, early use of neuraminidase inhibitors was found to be protective (Odds ratio: 0.17, confidence interval: 0.03-0.77, p = 0.022), nosocomial infections (OR: 5.7, CI: 1.84-18, p = 0.013), presence of malignant disease (OR: 3.8, CI: 0.66-22.01, p = 0.133) significantly increased the likelihood of fatality. CONCLUSIONS: Early detection of the infection, allowing opportunity for the early use of neuraminidase inhibitors, was found to be important for prevention of fatality. Nosocomial bacterial infections and underlying malignant diseases increased the rate of fatality. BioMed Central 2014-06-10 /pmc/articles/PMC4080987/ /pubmed/24916566 http://dx.doi.org/10.1186/1471-2334-14-317 Text en Copyright © 2014 Ergönül et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Ergönül, Önder
Alan, Servet
Ak, Öznur
Sargın, Fatman
Kantürk, Arzu
Gündüz, Alper
Engin, Derya
Öncül, Oral
Balkan, Ilker Inanc
Ceylan, Bahadir
Benzonana, Nur
Yazıcı, Saadet
Şimşek, Funda
Uzun, Nuray
İnan, Asuman
Gulhan, Eren
Ciblak, Meral
Midilli, Kenan
Ozyurt, Mustafa
Badur, Selim
Gencer, Serap
Nazlıcan, Ozcan
Özer, Serdar
Özgüneş, Nail
Yıldırmak, Taner
Aslan, Turan
Göktaş, Pasa
Saltoğlu, Nese
Fincancı, Muzaffer
Dokucu, Ali Ihsan
Eraksoy, Haluk
Predictors of fatality in pandemic influenza A (H1N1) virus infection among adults
title Predictors of fatality in pandemic influenza A (H1N1) virus infection among adults
title_full Predictors of fatality in pandemic influenza A (H1N1) virus infection among adults
title_fullStr Predictors of fatality in pandemic influenza A (H1N1) virus infection among adults
title_full_unstemmed Predictors of fatality in pandemic influenza A (H1N1) virus infection among adults
title_short Predictors of fatality in pandemic influenza A (H1N1) virus infection among adults
title_sort predictors of fatality in pandemic influenza a (h1n1) virus infection among adults
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080987/
https://www.ncbi.nlm.nih.gov/pubmed/24916566
http://dx.doi.org/10.1186/1471-2334-14-317
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