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Activity of EGFR, mTOR and PI3K inhibitors in an isogenic breast cell line model

BACKGROUND: The epidermal growth factor receptor family is expressed in breast cancer, and agents targeting this pathway have single agent effects (e.g. traztuzumab). Development of resistance may be due to the presence of alternative pathways, particularly activation of the PI3K/Akt/MTOR pathway. W...

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Detalles Bibliográficos
Autores principales:	Glaysher, Sharon, Bolton, Louise M, Johnson, Penny, Torrance, Christopher, Cree, Ian A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080989/ https://www.ncbi.nlm.nih.gov/pubmed/24964744 http://dx.doi.org/10.1186/1756-0500-7-397

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