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Stabilizing Rescued Surface-Localized ΔF508 CFTR by Potentiation of Its Interaction with Na(+)/H(+) Exchanger Regulatory Factor 1
[Image: see text] Cystic fibrosis (CF) is a recessive genetic disease caused by mutations in CFTR, a plasma-membrane-localized anion channel. The most common mutation in CFTR, deletion of phenylalanine at residue 508 (ΔF508), causes misfolding of CFTR resulting in little or no protein at the plasma...
Autores principales: | Arora, Kavisha, Moon, Changsuk, Zhang, Weiqiang, Yarlagadda, Sunitha, Penmatsa, Himabindu, Ren, Aixia, Sinha, Chandrima, Naren, Anjaparavanda P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American
Chemical Society
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081048/ https://www.ncbi.nlm.nih.gov/pubmed/24945463 http://dx.doi.org/10.1021/bi401263h |
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