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Human AP endonuclease inefficiently removes abasic sites within G4 structures compared to duplex DNA

Excision repair processes are essential to maintain genome stability. A decrease in efficiency and fidelity of these pathways at regions of the genome that can assume non-canonical DNA structures has been proposed as a possible mechanism to explain the increased mutagenesis and consequent diseased s...

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Detalles Bibliográficos
Autores principales:	Broxson, Christopher, Hayner, Jaclyn N., Beckett, Joshua, Bloom, Linda B., Tornaletti, Silvia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081060/ https://www.ncbi.nlm.nih.gov/pubmed/24848015 http://dx.doi.org/10.1093/nar/gku417

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