Divergent LIN28-mRNA associations result in translational suppression upon the initiation of differentiation

LIN28 function is fundamental to the activity and behavior of human embryonic stem cells (hESCs) and induced pluripotent stem cells. Its main roles in these cell types are the regulation of translational efficiency and let-7 miRNA maturation. However, LIN28-associated mRNA cargo shifting and resulta...

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Detalles Bibliográficos
Autores principales: Tan, Shen Mynn, Altschuler, Gabriel, Zhao, Tian Yun, Ang, Haw Siang, Yang, Henry, Lim, Bing, Vardy, Leah, Hide, Winston, Thomson, Andrew M., Lareu, Ricky R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081066/
https://www.ncbi.nlm.nih.gov/pubmed/24860167
http://dx.doi.org/10.1093/nar/gku430

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