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Hyperactive Cdc2 kinase interferes with the response to broken replication forks by trapping S.pombe Crb2 in its mitotic T215 phosphorylated state

Although it is well established that Cdc2 kinase phosphorylates the DNA damage checkpoint protein Crb2(53BP1) in mitosis, the full impact of this modification is still unclear. The Tudor-BRCT domain protein Crb2 binds to modified histones at DNA lesions to mediate the activation of Chk1 by Rad3(ATR)...

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Detalles Bibliográficos
Autores principales:	Mahyous Saeyd, Salah Adam, Ewert-Krzemieniewska, Katarzyna, Liu, Boyin, Caspari, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081076/ https://www.ncbi.nlm.nih.gov/pubmed/24861625 http://dx.doi.org/10.1093/nar/gku452

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