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A deafness-associated tRNA(His) mutation alters the mitochondrial function, ROS production and membrane potential

In this report, we investigated the molecular genetic mechanism underlying the deafness-associated mitochondrial tRNA(His) 12201T>C mutation. The destabilization of a highly conserved base-pairing (5A-68U) by the m.12201T>C mutation alters structure and function of tRNA(His). Using cybrids con...

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Detalles Bibliográficos
Autores principales:	Gong, Shasha, Peng, Yanyan, Jiang, Pingping, Wang, Meng, Fan, Mingjie, Wang, Xinjian, Zhou, Hong, Li, Huawei, Yan, Qingfeng, Huang, Taosheng, Guan, Min-Xin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081083/ https://www.ncbi.nlm.nih.gov/pubmed/24920829 http://dx.doi.org/10.1093/nar/gku466

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