Regulation of L1 expression and retrotransposition by melatonin and its receptor: implications for cancer risk associated with light exposure at night

Expression of long interspersed element-1 (L1) is upregulated in many human malignancies. L1 can introduce genomic instability via insertional mutagenesis and DNA double-strand breaks, both of which may promote cancer. Light exposure at night, a recently recognized carcinogen, is associated with an...

Descripción completa

Detalles Bibliográficos
Autores principales: deHaro, Dawn, Kines, Kristine J., Sokolowski, Mark, Dauchy, Robert T., Streva, Vincent A., Hill, Steven M., Hanifin, John P., Brainard, George C., Blask, David E., Belancio, Victoria P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081101/
https://www.ncbi.nlm.nih.gov/pubmed/24914052
http://dx.doi.org/10.1093/nar/gku503

Ejemplares similares

Ejemplares similares