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Design and evaluation of locked nucleic acid-based splice-switching oligonucleotides in vitro

Antisense-mediated modulation of pre-mRNA splicing is an attractive therapeutic strategy for genetic diseases. Currently, there are few examples of modulation of pre-mRNA splicing using locked nucleic acid (LNA) antisense oligonucleotides, and, in particular, no systematic study has addressed the op...

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Detalles Bibliográficos
Autores principales:	Shimo, Takenori, Tachibana, Keisuke, Saito, Kiwamu, Yoshida, Tokuyuki, Tomita, Erisa, Waki, Reiko, Yamamoto, Tsuyoshi, Doi, Takefumi, Inoue, Takao, Kawakami, Junji, Obika, Satoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Synthetic Biology and Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081108/ https://www.ncbi.nlm.nih.gov/pubmed/24935206 http://dx.doi.org/10.1093/nar/gku512

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