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Ameloblastic carcinoma: An analysis of 12 cases with a review of the literature
The diagnosis of ameloblastic carcinoma is often difficult and the optimal treatment methods remain controversial. The current study retrospectively investigated the optimal diagnosis and treatment methods of 12 ameloblastic carcinoma patients at the West China Hospital of Stomatology, Sichuan Unive...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081393/ https://www.ncbi.nlm.nih.gov/pubmed/25013517 http://dx.doi.org/10.3892/ol.2014.2230 |
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author | LI, JIA DU, HONGMING LI, PENG ZHANG, JINGKUI TIAN, WEIDONG TANG, WEI |
author_facet | LI, JIA DU, HONGMING LI, PENG ZHANG, JINGKUI TIAN, WEIDONG TANG, WEI |
author_sort | LI, JIA |
collection | PubMed |
description | The diagnosis of ameloblastic carcinoma is often difficult and the optimal treatment methods remain controversial. The current study retrospectively investigated the optimal diagnosis and treatment methods of 12 ameloblastic carcinoma patients at the West China Hospital of Stomatology, Sichuan University (Chengdu, China), and 20 patients selected from the PubMed database, were reviewed. The clinical features, diagnosis and outcome of the different treatments were evaluated. Ameloblastic carcinoma occurred in 12 out of a total of 538 ameloblastoma patients; the majority were of the primary type. Of the 538 ameloblastoma patients, 294 were male, 244 were female with a male to female ratio of 1.2:1. The predilection age is 20–30 years, which accounts for 40% of the total. In total, 461 cases were in the mandible and 77 were located in the maxilla. The cure rate of the primary type and the recurrence rate of the secondary type tumors were higher in the patients from the West China Hospital of Stomatology compared with those reported in the literature. In particular, a case with a long-term survival of 30 years is presented, which is considered to be relatively rare. The evolution of the clinical course has experienced three stages: Ameloblastoma (1978) followed by metastatic ameloblastoma (2000) and finally ameloblastic carcinoma (2008). To avoid recurrence, wide local excision with postoperative radiation therapy is required. While novel therapeutic regimens should also be considered as appropriate, including carbon ion therapy and Gamma Knife stereotactic radiosurgery. However, controlled studies with larger groups of patients are required to increase the accuracy of results. |
format | Online Article Text |
id | pubmed-4081393 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-40813932014-07-10 Ameloblastic carcinoma: An analysis of 12 cases with a review of the literature LI, JIA DU, HONGMING LI, PENG ZHANG, JINGKUI TIAN, WEIDONG TANG, WEI Oncol Lett Articles The diagnosis of ameloblastic carcinoma is often difficult and the optimal treatment methods remain controversial. The current study retrospectively investigated the optimal diagnosis and treatment methods of 12 ameloblastic carcinoma patients at the West China Hospital of Stomatology, Sichuan University (Chengdu, China), and 20 patients selected from the PubMed database, were reviewed. The clinical features, diagnosis and outcome of the different treatments were evaluated. Ameloblastic carcinoma occurred in 12 out of a total of 538 ameloblastoma patients; the majority were of the primary type. Of the 538 ameloblastoma patients, 294 were male, 244 were female with a male to female ratio of 1.2:1. The predilection age is 20–30 years, which accounts for 40% of the total. In total, 461 cases were in the mandible and 77 were located in the maxilla. The cure rate of the primary type and the recurrence rate of the secondary type tumors were higher in the patients from the West China Hospital of Stomatology compared with those reported in the literature. In particular, a case with a long-term survival of 30 years is presented, which is considered to be relatively rare. The evolution of the clinical course has experienced three stages: Ameloblastoma (1978) followed by metastatic ameloblastoma (2000) and finally ameloblastic carcinoma (2008). To avoid recurrence, wide local excision with postoperative radiation therapy is required. While novel therapeutic regimens should also be considered as appropriate, including carbon ion therapy and Gamma Knife stereotactic radiosurgery. However, controlled studies with larger groups of patients are required to increase the accuracy of results. D.A. Spandidos 2014-08 2014-06-05 /pmc/articles/PMC4081393/ /pubmed/25013517 http://dx.doi.org/10.3892/ol.2014.2230 Text en Copyright © 2014, Spandidos Publications http://creativecommons.org/licenses/by/3.0 This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Articles LI, JIA DU, HONGMING LI, PENG ZHANG, JINGKUI TIAN, WEIDONG TANG, WEI Ameloblastic carcinoma: An analysis of 12 cases with a review of the literature |
title | Ameloblastic carcinoma: An analysis of 12 cases with a review of the literature |
title_full | Ameloblastic carcinoma: An analysis of 12 cases with a review of the literature |
title_fullStr | Ameloblastic carcinoma: An analysis of 12 cases with a review of the literature |
title_full_unstemmed | Ameloblastic carcinoma: An analysis of 12 cases with a review of the literature |
title_short | Ameloblastic carcinoma: An analysis of 12 cases with a review of the literature |
title_sort | ameloblastic carcinoma: an analysis of 12 cases with a review of the literature |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081393/ https://www.ncbi.nlm.nih.gov/pubmed/25013517 http://dx.doi.org/10.3892/ol.2014.2230 |
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