Cargando…

Combination Effects of Peramivir and Favipiravir against Oseltamivir-Resistant 2009 Pandemic Influenza A(H1N1) Infection in Mice

Antiviral drugs are being used for therapeutic purposes against influenza illness in humans. However, antiviral-resistant variants often nullify the effectiveness of antivirals. Combined medications, as seen in the treatment of cancers and other infectious diseases, have been suggested as an option...

Descripción completa

Detalles Bibliográficos
Autores principales: Park, Sehee, Kim, Jin Il, Lee, Ilseob, Lee, Sangmoo, Hwang, Min-Woong, Bae, Joon-Yong, Heo, Jun, Kim, Donghwan, Jang, Seok-Il, Kim, Hyejin, Cheong, Hee Jin, Song, Jin-Won, Song, Ki-Joon, Baek, Luck Ju, Park, Man-Seong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081560/
https://www.ncbi.nlm.nih.gov/pubmed/24992479
http://dx.doi.org/10.1371/journal.pone.0101325
_version_ 1782324121146753024
author Park, Sehee
Kim, Jin Il
Lee, Ilseob
Lee, Sangmoo
Hwang, Min-Woong
Bae, Joon-Yong
Heo, Jun
Kim, Donghwan
Jang, Seok-Il
Kim, Hyejin
Cheong, Hee Jin
Song, Jin-Won
Song, Ki-Joon
Baek, Luck Ju
Park, Man-Seong
author_facet Park, Sehee
Kim, Jin Il
Lee, Ilseob
Lee, Sangmoo
Hwang, Min-Woong
Bae, Joon-Yong
Heo, Jun
Kim, Donghwan
Jang, Seok-Il
Kim, Hyejin
Cheong, Hee Jin
Song, Jin-Won
Song, Ki-Joon
Baek, Luck Ju
Park, Man-Seong
author_sort Park, Sehee
collection PubMed
description Antiviral drugs are being used for therapeutic purposes against influenza illness in humans. However, antiviral-resistant variants often nullify the effectiveness of antivirals. Combined medications, as seen in the treatment of cancers and other infectious diseases, have been suggested as an option for the control of antiviral-resistant influenza viruses. Here, we evaluated the therapeutic value of combination therapy against oseltamivir-resistant 2009 pandemic influenza H1N1 virus infection in DBA/2 mice. Mice were treated for five days with favipiravir and peramivir starting 4 hours after lethal challenge. Compared with either monotherapy, combination therapy saved more mice from viral lethality and resulted in increased antiviral efficacy in the lungs of infected mice. Furthermore, the synergism between the two antivirals, which was consistent with the survival outcomes of combination therapy, indicated that favipiravir could serve as a critical agent of combination therapy for the control of oseltamivir-resistant strains. Our results provide new insight into the feasibility of favipiravir in combination therapy against oseltamivir-resistant influenza virus infection.
format Online
Article
Text
id pubmed-4081560
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-40815602014-07-10 Combination Effects of Peramivir and Favipiravir against Oseltamivir-Resistant 2009 Pandemic Influenza A(H1N1) Infection in Mice Park, Sehee Kim, Jin Il Lee, Ilseob Lee, Sangmoo Hwang, Min-Woong Bae, Joon-Yong Heo, Jun Kim, Donghwan Jang, Seok-Il Kim, Hyejin Cheong, Hee Jin Song, Jin-Won Song, Ki-Joon Baek, Luck Ju Park, Man-Seong PLoS One Research Article Antiviral drugs are being used for therapeutic purposes against influenza illness in humans. However, antiviral-resistant variants often nullify the effectiveness of antivirals. Combined medications, as seen in the treatment of cancers and other infectious diseases, have been suggested as an option for the control of antiviral-resistant influenza viruses. Here, we evaluated the therapeutic value of combination therapy against oseltamivir-resistant 2009 pandemic influenza H1N1 virus infection in DBA/2 mice. Mice were treated for five days with favipiravir and peramivir starting 4 hours after lethal challenge. Compared with either monotherapy, combination therapy saved more mice from viral lethality and resulted in increased antiviral efficacy in the lungs of infected mice. Furthermore, the synergism between the two antivirals, which was consistent with the survival outcomes of combination therapy, indicated that favipiravir could serve as a critical agent of combination therapy for the control of oseltamivir-resistant strains. Our results provide new insight into the feasibility of favipiravir in combination therapy against oseltamivir-resistant influenza virus infection. Public Library of Science 2014-07-03 /pmc/articles/PMC4081560/ /pubmed/24992479 http://dx.doi.org/10.1371/journal.pone.0101325 Text en © 2014 Park et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Park, Sehee
Kim, Jin Il
Lee, Ilseob
Lee, Sangmoo
Hwang, Min-Woong
Bae, Joon-Yong
Heo, Jun
Kim, Donghwan
Jang, Seok-Il
Kim, Hyejin
Cheong, Hee Jin
Song, Jin-Won
Song, Ki-Joon
Baek, Luck Ju
Park, Man-Seong
Combination Effects of Peramivir and Favipiravir against Oseltamivir-Resistant 2009 Pandemic Influenza A(H1N1) Infection in Mice
title Combination Effects of Peramivir and Favipiravir against Oseltamivir-Resistant 2009 Pandemic Influenza A(H1N1) Infection in Mice
title_full Combination Effects of Peramivir and Favipiravir against Oseltamivir-Resistant 2009 Pandemic Influenza A(H1N1) Infection in Mice
title_fullStr Combination Effects of Peramivir and Favipiravir against Oseltamivir-Resistant 2009 Pandemic Influenza A(H1N1) Infection in Mice
title_full_unstemmed Combination Effects of Peramivir and Favipiravir against Oseltamivir-Resistant 2009 Pandemic Influenza A(H1N1) Infection in Mice
title_short Combination Effects of Peramivir and Favipiravir against Oseltamivir-Resistant 2009 Pandemic Influenza A(H1N1) Infection in Mice
title_sort combination effects of peramivir and favipiravir against oseltamivir-resistant 2009 pandemic influenza a(h1n1) infection in mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081560/
https://www.ncbi.nlm.nih.gov/pubmed/24992479
http://dx.doi.org/10.1371/journal.pone.0101325
work_keys_str_mv AT parksehee combinationeffectsofperamivirandfavipiraviragainstoseltamivirresistant2009pandemicinfluenzaah1n1infectioninmice
AT kimjinil combinationeffectsofperamivirandfavipiraviragainstoseltamivirresistant2009pandemicinfluenzaah1n1infectioninmice
AT leeilseob combinationeffectsofperamivirandfavipiraviragainstoseltamivirresistant2009pandemicinfluenzaah1n1infectioninmice
AT leesangmoo combinationeffectsofperamivirandfavipiraviragainstoseltamivirresistant2009pandemicinfluenzaah1n1infectioninmice
AT hwangminwoong combinationeffectsofperamivirandfavipiraviragainstoseltamivirresistant2009pandemicinfluenzaah1n1infectioninmice
AT baejoonyong combinationeffectsofperamivirandfavipiraviragainstoseltamivirresistant2009pandemicinfluenzaah1n1infectioninmice
AT heojun combinationeffectsofperamivirandfavipiraviragainstoseltamivirresistant2009pandemicinfluenzaah1n1infectioninmice
AT kimdonghwan combinationeffectsofperamivirandfavipiraviragainstoseltamivirresistant2009pandemicinfluenzaah1n1infectioninmice
AT jangseokil combinationeffectsofperamivirandfavipiraviragainstoseltamivirresistant2009pandemicinfluenzaah1n1infectioninmice
AT kimhyejin combinationeffectsofperamivirandfavipiraviragainstoseltamivirresistant2009pandemicinfluenzaah1n1infectioninmice
AT cheongheejin combinationeffectsofperamivirandfavipiraviragainstoseltamivirresistant2009pandemicinfluenzaah1n1infectioninmice
AT songjinwon combinationeffectsofperamivirandfavipiraviragainstoseltamivirresistant2009pandemicinfluenzaah1n1infectioninmice
AT songkijoon combinationeffectsofperamivirandfavipiraviragainstoseltamivirresistant2009pandemicinfluenzaah1n1infectioninmice
AT baekluckju combinationeffectsofperamivirandfavipiraviragainstoseltamivirresistant2009pandemicinfluenzaah1n1infectioninmice
AT parkmanseong combinationeffectsofperamivirandfavipiraviragainstoseltamivirresistant2009pandemicinfluenzaah1n1infectioninmice