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Human Herpes Viruses Are Associated with Classic Fever of Unknown Origin (FUO) in Beijing Patients
BACKGROUND: Few reports have examined the viral aetiology of fever of unknown origin (FUO). OBJECTIVE: This study determined the prevalence of human herpes virus (HHV) DNA in blood of Chinese patients with classic FUO using the polymerase chain reaction (PCR) and explored the possible role of HHV. S...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081597/ https://www.ncbi.nlm.nih.gov/pubmed/24991930 http://dx.doi.org/10.1371/journal.pone.0101619 |
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author | Zhou, Weimin Tan, Xinyi Li, Yamin Tan, Wenjie |
author_facet | Zhou, Weimin Tan, Xinyi Li, Yamin Tan, Wenjie |
author_sort | Zhou, Weimin |
collection | PubMed |
description | BACKGROUND: Few reports have examined the viral aetiology of fever of unknown origin (FUO). OBJECTIVE: This study determined the prevalence of human herpes virus (HHV) DNA in blood of Chinese patients with classic FUO using the polymerase chain reaction (PCR) and explored the possible role of HHV. STUDY DESIGN: Blood samples were collected from 186 patients (151 children, 35 adults) with classic FUO and 143 normal individuals in Beijing during the years 2009–2012. The HHV DNA, including Herpes simplex virus (HSV)-1/2, Varicella zoster virus (VZV), Cytomegalovirus (CMV), Epstein–Barr virus (EBV), and Human herpes virus (HHV)-6 and -7, was detected by multiplex PCR. The epidemiological and clinical features were also analysed. RESULTS: HHV DNA was detected in 63 (33.9%) of the FUO patients, and the prevalence of EBV and HHV-6 was significantly higher than in the normal cohort. HHV co-infection was also frequent (10.2%) in the patients with FUO. The majority of patients with HHV infection present with a fever only. Our data also revealed that EBV infection was associated with hepatitis and abnormal blood indices, HHV-6 was associated with a cough, and HHV-7 was associated with hepatitis. CONCLUSIONS: HHVs are associated with Chinese patients (especially for children) with classic FUO. Our study adds perspective to the aetiological and clinical characteristics of classic FUO in beijing patients. |
format | Online Article Text |
id | pubmed-4081597 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-40815972014-07-10 Human Herpes Viruses Are Associated with Classic Fever of Unknown Origin (FUO) in Beijing Patients Zhou, Weimin Tan, Xinyi Li, Yamin Tan, Wenjie PLoS One Research Article BACKGROUND: Few reports have examined the viral aetiology of fever of unknown origin (FUO). OBJECTIVE: This study determined the prevalence of human herpes virus (HHV) DNA in blood of Chinese patients with classic FUO using the polymerase chain reaction (PCR) and explored the possible role of HHV. STUDY DESIGN: Blood samples were collected from 186 patients (151 children, 35 adults) with classic FUO and 143 normal individuals in Beijing during the years 2009–2012. The HHV DNA, including Herpes simplex virus (HSV)-1/2, Varicella zoster virus (VZV), Cytomegalovirus (CMV), Epstein–Barr virus (EBV), and Human herpes virus (HHV)-6 and -7, was detected by multiplex PCR. The epidemiological and clinical features were also analysed. RESULTS: HHV DNA was detected in 63 (33.9%) of the FUO patients, and the prevalence of EBV and HHV-6 was significantly higher than in the normal cohort. HHV co-infection was also frequent (10.2%) in the patients with FUO. The majority of patients with HHV infection present with a fever only. Our data also revealed that EBV infection was associated with hepatitis and abnormal blood indices, HHV-6 was associated with a cough, and HHV-7 was associated with hepatitis. CONCLUSIONS: HHVs are associated with Chinese patients (especially for children) with classic FUO. Our study adds perspective to the aetiological and clinical characteristics of classic FUO in beijing patients. Public Library of Science 2014-07-03 /pmc/articles/PMC4081597/ /pubmed/24991930 http://dx.doi.org/10.1371/journal.pone.0101619 Text en © 2014 Zhou et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Zhou, Weimin Tan, Xinyi Li, Yamin Tan, Wenjie Human Herpes Viruses Are Associated with Classic Fever of Unknown Origin (FUO) in Beijing Patients |
title | Human Herpes Viruses Are Associated with Classic Fever of Unknown Origin (FUO) in Beijing Patients |
title_full | Human Herpes Viruses Are Associated with Classic Fever of Unknown Origin (FUO) in Beijing Patients |
title_fullStr | Human Herpes Viruses Are Associated with Classic Fever of Unknown Origin (FUO) in Beijing Patients |
title_full_unstemmed | Human Herpes Viruses Are Associated with Classic Fever of Unknown Origin (FUO) in Beijing Patients |
title_short | Human Herpes Viruses Are Associated with Classic Fever of Unknown Origin (FUO) in Beijing Patients |
title_sort | human herpes viruses are associated with classic fever of unknown origin (fuo) in beijing patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081597/ https://www.ncbi.nlm.nih.gov/pubmed/24991930 http://dx.doi.org/10.1371/journal.pone.0101619 |
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