Downregulation of Blood-Brain Barrier Phenotype by Proinflammatory Cytokines Involves NADPH Oxidase-Dependent ROS Generation: Consequences for Interendothelial Adherens and Tight Junctions

BACKGROUND AND OBJECTIVES: Blood-brain barrier (BBB) dysfunction is an integral feature of neurological disorders and involves the action of multiple proinflammatory cytokines on the microvascular endothelial cells lining cerebral capillaries. There is still however, considerable ambiguity throughou...

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Detalles Bibliográficos
Autores principales: Rochfort, Keith D., Collins, Laura E., Murphy, Ronan P., Cummins, Philip M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081725/
https://www.ncbi.nlm.nih.gov/pubmed/24992685
http://dx.doi.org/10.1371/journal.pone.0101815

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