Pulmonary Infection with Hypervirulent Mycobacteria Reveals a Crucial Role for the P2X7 Receptor in Aggressive Forms of Tuberculosis

The purinergic P2X7 receptor (P2X7R) is a sensor of extracellular ATP, a damage-associated molecule that is released from necrotic cells and that induces pro-inflammatory cytokine production and cell death. To investigate whether the innate immune response to damage signals could contribute to the d...

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Detalles Bibliográficos
Autores principales: Amaral, Eduardo P., Ribeiro, Simone C. M., Lanes, Verônica R., Almeida, Fabrício M., de Andrade, Marcelle R. M., Bomfim, Caio Cesar Barbosa, Salles, Érika M., Bortoluci, Karina R., Coutinho-Silva, Robson, Hirata, Mario H., Alvarez, José M., Lasunskaia, Elena B., D'Império-Lima, Maria Regina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081775/
https://www.ncbi.nlm.nih.gov/pubmed/24991816
http://dx.doi.org/10.1371/journal.ppat.1004188

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