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Bottom-Up Low Molecular Weight Heparin Analysis Using Liquid Chromatography-Fourier Transform Mass Spectrometry for Extensive Characterization

[Image: see text] Low molecular weight heparins (LMWHs) are heterogeneous, polydisperse, and highly negatively charged mixtures of glycosaminoglycan chains prescribed as anticoagulants. The detailed characterization of LMWH is important for the drug quality assurance and for new drug research and de...

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Detalles Bibliográficos
Autores principales: Li, Guoyun, Steppich, Julia, Wang, Zhenyu, Sun, Yi, Xue, Changhu, Linhardt, Robert J., Li, Lingyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082394/
https://www.ncbi.nlm.nih.gov/pubmed/24905078
http://dx.doi.org/10.1021/ac501301v