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Inhibition of the checkpoint kinase Chk1 induces DNA damage and cell death in human Leukemia and Lymphoma cells

BACKGROUND: Chk1 forms a core component of the DNA damage response and small molecule inhibitors are currently being investigated in the clinic as cytotoxic chemotherapy potentiators. Recent evidence suggests that Chk1 inhibitors may demonstrate significant single agent activity in tumors with speci...

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Detalles Bibliográficos
Autores principales:	Bryant, Christopher, Scriven, Kirsten, Massey, Andrew J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082411/ https://www.ncbi.nlm.nih.gov/pubmed/24913641 http://dx.doi.org/10.1186/1476-4598-13-147

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