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Pharmacokinetics, clearance, and biosafety of polyethylene glycol-coated hollow gold nanospheres

OBJECTIVE: Gold nanoparticles have attracted enormous interest as potential theranostic agents. However, little is known about the long-term elimination and systemic toxicity of gold nanoparticles in the literature. Hollow gold nanospheres (HAuNS) is a class of photothermal conducting agent that hav...

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Autores principales: You, Jian, Zhou, Jialin, Zhou, Min, Liu, Yang, Robertson, J David, Liang, Dong, Van Pelt, Carolyn, Li, Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082425/
https://www.ncbi.nlm.nih.gov/pubmed/24886070
http://dx.doi.org/10.1186/1743-8977-11-26
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author You, Jian
Zhou, Jialin
Zhou, Min
Liu, Yang
Robertson, J David
Liang, Dong
Van Pelt, Carolyn
Li, Chun
author_facet You, Jian
Zhou, Jialin
Zhou, Min
Liu, Yang
Robertson, J David
Liang, Dong
Van Pelt, Carolyn
Li, Chun
author_sort You, Jian
collection PubMed
description OBJECTIVE: Gold nanoparticles have attracted enormous interest as potential theranostic agents. However, little is known about the long-term elimination and systemic toxicity of gold nanoparticles in the literature. Hollow gold nanospheres (HAuNS) is a class of photothermal conducting agent that have shown promises in photoacoustic imaging, photothermal ablation therapy, and drug delivery. It’s very necessary to make clear the biosafety of HAuNS for its further application. METHODS: We investigated the cytotoxicity, complement activation, and platelet aggregation of polyethylene glycol (PEG)-coated HAuNS (PEG-HAuNS, average diameter of 63 nm) in vitro and their pharmacokinetics, biodistribution, organ elimination, hematology, clinical chemistry, acute toxicity, and chronic toxicity in mice. RESULTS: PEG-HAuNS did not induce detectable activation of the complement system and did not induce detectable platelet aggregation. The blood half-life of PEG-HAuNS in mice was 8.19 ± 1.4 hr. The single effective dose of PEG-HAuNS in photothermal ablation therapy was determined to be 12.5 mg/kg. PEG-HAuNS caused no adverse effects after 10 daily intravenous injections over a 2-week period at a dose of 12.5 mg/kg per injection (accumulated dose: 125 mg/kg). Quantitative analysis of the muscle, liver, spleen, and kidney revealed that the levels of Au decreased 45.2%, 28.6%, 41.7%, and 40.8%, respectively, from day 14 to day 90 after the first intravenous injection, indicating that PEG-HAuNS was slowly cleared from these organs in mice. CONCLUSION: Our data support the use of PEG-HAuNS as a promising photothermal conducting agent.
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spelling pubmed-40824252014-07-05 Pharmacokinetics, clearance, and biosafety of polyethylene glycol-coated hollow gold nanospheres You, Jian Zhou, Jialin Zhou, Min Liu, Yang Robertson, J David Liang, Dong Van Pelt, Carolyn Li, Chun Part Fibre Toxicol Research OBJECTIVE: Gold nanoparticles have attracted enormous interest as potential theranostic agents. However, little is known about the long-term elimination and systemic toxicity of gold nanoparticles in the literature. Hollow gold nanospheres (HAuNS) is a class of photothermal conducting agent that have shown promises in photoacoustic imaging, photothermal ablation therapy, and drug delivery. It’s very necessary to make clear the biosafety of HAuNS for its further application. METHODS: We investigated the cytotoxicity, complement activation, and platelet aggregation of polyethylene glycol (PEG)-coated HAuNS (PEG-HAuNS, average diameter of 63 nm) in vitro and their pharmacokinetics, biodistribution, organ elimination, hematology, clinical chemistry, acute toxicity, and chronic toxicity in mice. RESULTS: PEG-HAuNS did not induce detectable activation of the complement system and did not induce detectable platelet aggregation. The blood half-life of PEG-HAuNS in mice was 8.19 ± 1.4 hr. The single effective dose of PEG-HAuNS in photothermal ablation therapy was determined to be 12.5 mg/kg. PEG-HAuNS caused no adverse effects after 10 daily intravenous injections over a 2-week period at a dose of 12.5 mg/kg per injection (accumulated dose: 125 mg/kg). Quantitative analysis of the muscle, liver, spleen, and kidney revealed that the levels of Au decreased 45.2%, 28.6%, 41.7%, and 40.8%, respectively, from day 14 to day 90 after the first intravenous injection, indicating that PEG-HAuNS was slowly cleared from these organs in mice. CONCLUSION: Our data support the use of PEG-HAuNS as a promising photothermal conducting agent. BioMed Central 2014-05-30 /pmc/articles/PMC4082425/ /pubmed/24886070 http://dx.doi.org/10.1186/1743-8977-11-26 Text en Copyright © 2014 You et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
You, Jian
Zhou, Jialin
Zhou, Min
Liu, Yang
Robertson, J David
Liang, Dong
Van Pelt, Carolyn
Li, Chun
Pharmacokinetics, clearance, and biosafety of polyethylene glycol-coated hollow gold nanospheres
title Pharmacokinetics, clearance, and biosafety of polyethylene glycol-coated hollow gold nanospheres
title_full Pharmacokinetics, clearance, and biosafety of polyethylene glycol-coated hollow gold nanospheres
title_fullStr Pharmacokinetics, clearance, and biosafety of polyethylene glycol-coated hollow gold nanospheres
title_full_unstemmed Pharmacokinetics, clearance, and biosafety of polyethylene glycol-coated hollow gold nanospheres
title_short Pharmacokinetics, clearance, and biosafety of polyethylene glycol-coated hollow gold nanospheres
title_sort pharmacokinetics, clearance, and biosafety of polyethylene glycol-coated hollow gold nanospheres
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082425/
https://www.ncbi.nlm.nih.gov/pubmed/24886070
http://dx.doi.org/10.1186/1743-8977-11-26
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