The Rodin-Ohno hypothesis that two enzyme superfamilies descended from one ancestral gene: an unlikely scenario for the origins of translation that will not be dismissed

BACKGROUND: Because amino acid activation is rate-limiting for uncatalyzed protein synthesis, it is a key puzzle in understanding the origin of the genetic code. Two unrelated classes (I and II) of contemporary aminoacyl-tRNA synthetases (aaRS) now translate the code. Observing that codons for the m...

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Detalles Bibliográficos
Autores principales: Carter, Charles W, Li, Li, Weinreb, Violetta, Collier, Martha, Gonzalez-Rivera, Katiria, Jimenez-Rodriguez, Mariel, Erdogan, Ozgün, Kuhlman, Brian, Ambroggio, Xavier, Williams, Tishan, Chandrasekharan, S Niranj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082485/
https://www.ncbi.nlm.nih.gov/pubmed/24927791
http://dx.doi.org/10.1186/1745-6150-9-11

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