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Vitamin D and assisted reproduction technologies: current concepts

Accumulating evidence from animal and human studies suggests that vitamin D is involved in many functions of the human reproductive system in both genders, but no comprehensive analysis of the potential relationship between vitamin D status and Assisted Reproduction Technologies (ART) outcomes is cu...

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Autores principales: Vanni, Valeria S, Vigano', Paola, Somigliana, Edgardo, Papaleo, Enrico, Paffoni, Alessio, Pagliardini, Luca, Candiani, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082488/
https://www.ncbi.nlm.nih.gov/pubmed/24884987
http://dx.doi.org/10.1186/1477-7827-12-47
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author Vanni, Valeria S
Vigano', Paola
Somigliana, Edgardo
Papaleo, Enrico
Paffoni, Alessio
Pagliardini, Luca
Candiani, Massimo
author_facet Vanni, Valeria S
Vigano', Paola
Somigliana, Edgardo
Papaleo, Enrico
Paffoni, Alessio
Pagliardini, Luca
Candiani, Massimo
author_sort Vanni, Valeria S
collection PubMed
description Accumulating evidence from animal and human studies suggests that vitamin D is involved in many functions of the human reproductive system in both genders, but no comprehensive analysis of the potential relationship between vitamin D status and Assisted Reproduction Technologies (ART) outcomes is currently available. On this basis, the purpose of this systematic review and meta-analysis was to perform an in-depth evaluation of clinical studies assessing whether vitamin D status of patients undergoing ART could be related to cycle outcome variables. This issue is of interest considering that vitamin D deficiency is easily amenable to correction and oral vitamin D supplementation is cheap and without significant side effects. Surprisingly, no studies are currently available assessing vitamin D status among male partners of couples undergoing ART, while seven studies on vitamin D status of women undergoing controlled ovarian hyperstimulation (COH) for ART were found and included in the review. Results show that vitamin D deficiency is highly prevalent among women undergoing COH, ranging from 21% to 31% across studies conducted in Western countries and reaching 75-99% in Iranian studies. Data on vitamin D deficiency (25-hydroxyvitamin D serum levels <20 ng/ml) in relation to ART outcomes could be extracted from three studies and included in the meta-analysis, yielding a common risk ratio (RR) of 0.89 (95% CI 0.53-1.49) and showing a lower but not statistically significant likelihood of clinical pregnancy for vitamin-D-deficient women compared with vitamin-D-sufficient patients. In conclusion, there is insufficient evidence to support the routine assessment of vitamin D status to predict the clinical pregnancy rate in couples undergoing ART. The partly conflicting results of the available studies, potentially explaining the lack of statistical significance for a negative influence of vitamin D deficiency on clinical pregnancy rate, are likely secondary to confounders and insufficient sample size, and further larger cohort and randomised controlled studies are required.
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spelling pubmed-40824882014-07-06 Vitamin D and assisted reproduction technologies: current concepts Vanni, Valeria S Vigano', Paola Somigliana, Edgardo Papaleo, Enrico Paffoni, Alessio Pagliardini, Luca Candiani, Massimo Reprod Biol Endocrinol Review Accumulating evidence from animal and human studies suggests that vitamin D is involved in many functions of the human reproductive system in both genders, but no comprehensive analysis of the potential relationship between vitamin D status and Assisted Reproduction Technologies (ART) outcomes is currently available. On this basis, the purpose of this systematic review and meta-analysis was to perform an in-depth evaluation of clinical studies assessing whether vitamin D status of patients undergoing ART could be related to cycle outcome variables. This issue is of interest considering that vitamin D deficiency is easily amenable to correction and oral vitamin D supplementation is cheap and without significant side effects. Surprisingly, no studies are currently available assessing vitamin D status among male partners of couples undergoing ART, while seven studies on vitamin D status of women undergoing controlled ovarian hyperstimulation (COH) for ART were found and included in the review. Results show that vitamin D deficiency is highly prevalent among women undergoing COH, ranging from 21% to 31% across studies conducted in Western countries and reaching 75-99% in Iranian studies. Data on vitamin D deficiency (25-hydroxyvitamin D serum levels <20 ng/ml) in relation to ART outcomes could be extracted from three studies and included in the meta-analysis, yielding a common risk ratio (RR) of 0.89 (95% CI 0.53-1.49) and showing a lower but not statistically significant likelihood of clinical pregnancy for vitamin-D-deficient women compared with vitamin-D-sufficient patients. In conclusion, there is insufficient evidence to support the routine assessment of vitamin D status to predict the clinical pregnancy rate in couples undergoing ART. The partly conflicting results of the available studies, potentially explaining the lack of statistical significance for a negative influence of vitamin D deficiency on clinical pregnancy rate, are likely secondary to confounders and insufficient sample size, and further larger cohort and randomised controlled studies are required. BioMed Central 2014-05-31 /pmc/articles/PMC4082488/ /pubmed/24884987 http://dx.doi.org/10.1186/1477-7827-12-47 Text en Copyright © 2014 Vanni et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Vanni, Valeria S
Vigano', Paola
Somigliana, Edgardo
Papaleo, Enrico
Paffoni, Alessio
Pagliardini, Luca
Candiani, Massimo
Vitamin D and assisted reproduction technologies: current concepts
title Vitamin D and assisted reproduction technologies: current concepts
title_full Vitamin D and assisted reproduction technologies: current concepts
title_fullStr Vitamin D and assisted reproduction technologies: current concepts
title_full_unstemmed Vitamin D and assisted reproduction technologies: current concepts
title_short Vitamin D and assisted reproduction technologies: current concepts
title_sort vitamin d and assisted reproduction technologies: current concepts
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082488/
https://www.ncbi.nlm.nih.gov/pubmed/24884987
http://dx.doi.org/10.1186/1477-7827-12-47
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