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2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy
Large population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide polymorphisms (SNPs) of genes implicated in human immunology and inflammation as candidates for prognostic markers of breast cancer survival involving 1,804 oestrogen recep...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082638/ https://www.ncbi.nlm.nih.gov/pubmed/24937182 http://dx.doi.org/10.1038/ncomms5051 |
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author | Li, Jingmei Lindström, Linda S. Foo, Jia N. Rafiq, Sajjad Schmidt, Marjanka K. Pharoah, Paul D. P. Michailidou, Kyriaki Dennis, Joe Bolla, Manjeet K. Wang, Qin Van ‘t Veer, Laura J. Cornelissen, Sten Rutgers, Emiel Southey, Melissa C. Apicella, Carmel Dite, Gillian S. Hopper, John L. Fasching, Peter A. Haeberle, Lothar Ekici, Arif B. Beckmann, Matthias W. Blomqvist, Carl Muranen, Taru A. Aittomäki, Kristiina Lindblom, Annika Margolin, Sara Mannermaa, Arto Kosma, Veli-Matti Hartikainen, Jaana M. Kataja, Vesa Chenevix-Trench, Georgia Investigators, kConFab Phillips, Kelly-Anne McLachlan, Sue-Anne Lambrechts, Diether Thienpont, Bernard Smeets, Ann Wildiers, Hans Chang-Claude, Jenny Flesch-Janys, Dieter Seibold, Petra Rudolph, Anja Giles, Graham G. Baglietto, Laura Severi, Gianluca Haiman, Christopher A. Henderson, Brian E. Schumacher, Fredrick Le Marchand, Loic Kristensen, Vessela Alnæs, Grethe I. Grenaker Borresen-Dale, Anne-Lise Nord, Silje Winqvist, Robert Pylkäs, Katri Jukkola-Vuorinen, Arja Grip, Mervi Andrulis, Irene L. Knight, Julia A. Glendon, Gord Tchatchou, Sandrine Devilee, Peter Tollenaar, Robert Seynaeve, Caroline Hooning, Maartje Kriege, Mieke Hollestelle, Antoinette van den Ouweland, Ans Li, Yi Hamann, Ute Torres, Diana Ulmer, Hans U. Rüdiger, Thomas Shen, Chen-Yang Hsiung, Chia-Ni Wu, Pei-Ei Chen, Shou-Tung Teo, Soo Hwang Taib, Nur Aishah Mohd Har Yip, Cheng Fuang Ho, Gwo Matsuo, Keitaro Ito, Hidemi Iwata, Hiroji Tajima, Kazuo Kang, Daehee Choi, Ji-Yeob Park, Sue K. Yoo, Keun-Young Maishman, Tom Tapper, William J. Dunning, Alison Shah, Mitul Luben, Robert Brown, Judith Chuen Khor, Chiea Eccles, Diana M. Nevanlinna, Heli Easton, Douglas Humphreys, Keith Liu, Jianjun Hall, Per Czene, Kamila |
author_facet | Li, Jingmei Lindström, Linda S. Foo, Jia N. Rafiq, Sajjad Schmidt, Marjanka K. Pharoah, Paul D. P. Michailidou, Kyriaki Dennis, Joe Bolla, Manjeet K. Wang, Qin Van ‘t Veer, Laura J. Cornelissen, Sten Rutgers, Emiel Southey, Melissa C. Apicella, Carmel Dite, Gillian S. Hopper, John L. Fasching, Peter A. Haeberle, Lothar Ekici, Arif B. Beckmann, Matthias W. Blomqvist, Carl Muranen, Taru A. Aittomäki, Kristiina Lindblom, Annika Margolin, Sara Mannermaa, Arto Kosma, Veli-Matti Hartikainen, Jaana M. Kataja, Vesa Chenevix-Trench, Georgia Investigators, kConFab Phillips, Kelly-Anne McLachlan, Sue-Anne Lambrechts, Diether Thienpont, Bernard Smeets, Ann Wildiers, Hans Chang-Claude, Jenny Flesch-Janys, Dieter Seibold, Petra Rudolph, Anja Giles, Graham G. Baglietto, Laura Severi, Gianluca Haiman, Christopher A. Henderson, Brian E. Schumacher, Fredrick Le Marchand, Loic Kristensen, Vessela Alnæs, Grethe I. Grenaker Borresen-Dale, Anne-Lise Nord, Silje Winqvist, Robert Pylkäs, Katri Jukkola-Vuorinen, Arja Grip, Mervi Andrulis, Irene L. Knight, Julia A. Glendon, Gord Tchatchou, Sandrine Devilee, Peter Tollenaar, Robert Seynaeve, Caroline Hooning, Maartje Kriege, Mieke Hollestelle, Antoinette van den Ouweland, Ans Li, Yi Hamann, Ute Torres, Diana Ulmer, Hans U. Rüdiger, Thomas Shen, Chen-Yang Hsiung, Chia-Ni Wu, Pei-Ei Chen, Shou-Tung Teo, Soo Hwang Taib, Nur Aishah Mohd Har Yip, Cheng Fuang Ho, Gwo Matsuo, Keitaro Ito, Hidemi Iwata, Hiroji Tajima, Kazuo Kang, Daehee Choi, Ji-Yeob Park, Sue K. Yoo, Keun-Young Maishman, Tom Tapper, William J. Dunning, Alison Shah, Mitul Luben, Robert Brown, Judith Chuen Khor, Chiea Eccles, Diana M. Nevanlinna, Heli Easton, Douglas Humphreys, Keith Liu, Jianjun Hall, Per Czene, Kamila |
author_sort | Li, Jingmei |
collection | PubMed |
description | Large population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide polymorphisms (SNPs) of genes implicated in human immunology and inflammation as candidates for prognostic markers of breast cancer survival involving 1,804 oestrogen receptor (ER)-negative patients treated with chemotherapy (279 events) from 14 European studies in a prior large-scale genotyping experiment, which is part of the Collaborative Oncological Gene-environment Study (COGS) initiative. We carry out replication using Asian COGS samples (n=522, 53 events) and the Prospective Study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) study (n=315, 108 events). Rs4458204_A near CCL20 (2q36.3) is found to be associated with breast cancer-specific death at a genome-wide significant level (n=2,641, 440 events, combined allelic hazard ratio (HR)=1.81 (1.49–2.19); P for trend=1.90 × 10(−9)). Such survival-associated variants can represent ideal targets for tailored therapeutics, and may also enhance our current prognostic prediction capabilities. |
format | Online Article Text |
id | pubmed-4082638 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Nature Pub. Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-40826382014-07-10 2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy Li, Jingmei Lindström, Linda S. Foo, Jia N. Rafiq, Sajjad Schmidt, Marjanka K. Pharoah, Paul D. P. Michailidou, Kyriaki Dennis, Joe Bolla, Manjeet K. Wang, Qin Van ‘t Veer, Laura J. Cornelissen, Sten Rutgers, Emiel Southey, Melissa C. Apicella, Carmel Dite, Gillian S. Hopper, John L. Fasching, Peter A. Haeberle, Lothar Ekici, Arif B. Beckmann, Matthias W. Blomqvist, Carl Muranen, Taru A. Aittomäki, Kristiina Lindblom, Annika Margolin, Sara Mannermaa, Arto Kosma, Veli-Matti Hartikainen, Jaana M. Kataja, Vesa Chenevix-Trench, Georgia Investigators, kConFab Phillips, Kelly-Anne McLachlan, Sue-Anne Lambrechts, Diether Thienpont, Bernard Smeets, Ann Wildiers, Hans Chang-Claude, Jenny Flesch-Janys, Dieter Seibold, Petra Rudolph, Anja Giles, Graham G. Baglietto, Laura Severi, Gianluca Haiman, Christopher A. Henderson, Brian E. Schumacher, Fredrick Le Marchand, Loic Kristensen, Vessela Alnæs, Grethe I. Grenaker Borresen-Dale, Anne-Lise Nord, Silje Winqvist, Robert Pylkäs, Katri Jukkola-Vuorinen, Arja Grip, Mervi Andrulis, Irene L. Knight, Julia A. Glendon, Gord Tchatchou, Sandrine Devilee, Peter Tollenaar, Robert Seynaeve, Caroline Hooning, Maartje Kriege, Mieke Hollestelle, Antoinette van den Ouweland, Ans Li, Yi Hamann, Ute Torres, Diana Ulmer, Hans U. Rüdiger, Thomas Shen, Chen-Yang Hsiung, Chia-Ni Wu, Pei-Ei Chen, Shou-Tung Teo, Soo Hwang Taib, Nur Aishah Mohd Har Yip, Cheng Fuang Ho, Gwo Matsuo, Keitaro Ito, Hidemi Iwata, Hiroji Tajima, Kazuo Kang, Daehee Choi, Ji-Yeob Park, Sue K. Yoo, Keun-Young Maishman, Tom Tapper, William J. Dunning, Alison Shah, Mitul Luben, Robert Brown, Judith Chuen Khor, Chiea Eccles, Diana M. Nevanlinna, Heli Easton, Douglas Humphreys, Keith Liu, Jianjun Hall, Per Czene, Kamila Nat Commun Article Large population-based registry studies have shown that breast cancer prognosis is inherited. Here we analyse single-nucleotide polymorphisms (SNPs) of genes implicated in human immunology and inflammation as candidates for prognostic markers of breast cancer survival involving 1,804 oestrogen receptor (ER)-negative patients treated with chemotherapy (279 events) from 14 European studies in a prior large-scale genotyping experiment, which is part of the Collaborative Oncological Gene-environment Study (COGS) initiative. We carry out replication using Asian COGS samples (n=522, 53 events) and the Prospective Study of Outcomes in Sporadic versus Hereditary breast cancer (POSH) study (n=315, 108 events). Rs4458204_A near CCL20 (2q36.3) is found to be associated with breast cancer-specific death at a genome-wide significant level (n=2,641, 440 events, combined allelic hazard ratio (HR)=1.81 (1.49–2.19); P for trend=1.90 × 10(−9)). Such survival-associated variants can represent ideal targets for tailored therapeutics, and may also enhance our current prognostic prediction capabilities. Nature Pub. Group 2014-06-17 /pmc/articles/PMC4082638/ /pubmed/24937182 http://dx.doi.org/10.1038/ncomms5051 Text en Copyright © 2014, Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved. http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/ |
spellingShingle | Article Li, Jingmei Lindström, Linda S. Foo, Jia N. Rafiq, Sajjad Schmidt, Marjanka K. Pharoah, Paul D. P. Michailidou, Kyriaki Dennis, Joe Bolla, Manjeet K. Wang, Qin Van ‘t Veer, Laura J. Cornelissen, Sten Rutgers, Emiel Southey, Melissa C. Apicella, Carmel Dite, Gillian S. Hopper, John L. Fasching, Peter A. Haeberle, Lothar Ekici, Arif B. Beckmann, Matthias W. Blomqvist, Carl Muranen, Taru A. Aittomäki, Kristiina Lindblom, Annika Margolin, Sara Mannermaa, Arto Kosma, Veli-Matti Hartikainen, Jaana M. Kataja, Vesa Chenevix-Trench, Georgia Investigators, kConFab Phillips, Kelly-Anne McLachlan, Sue-Anne Lambrechts, Diether Thienpont, Bernard Smeets, Ann Wildiers, Hans Chang-Claude, Jenny Flesch-Janys, Dieter Seibold, Petra Rudolph, Anja Giles, Graham G. Baglietto, Laura Severi, Gianluca Haiman, Christopher A. Henderson, Brian E. Schumacher, Fredrick Le Marchand, Loic Kristensen, Vessela Alnæs, Grethe I. Grenaker Borresen-Dale, Anne-Lise Nord, Silje Winqvist, Robert Pylkäs, Katri Jukkola-Vuorinen, Arja Grip, Mervi Andrulis, Irene L. Knight, Julia A. Glendon, Gord Tchatchou, Sandrine Devilee, Peter Tollenaar, Robert Seynaeve, Caroline Hooning, Maartje Kriege, Mieke Hollestelle, Antoinette van den Ouweland, Ans Li, Yi Hamann, Ute Torres, Diana Ulmer, Hans U. Rüdiger, Thomas Shen, Chen-Yang Hsiung, Chia-Ni Wu, Pei-Ei Chen, Shou-Tung Teo, Soo Hwang Taib, Nur Aishah Mohd Har Yip, Cheng Fuang Ho, Gwo Matsuo, Keitaro Ito, Hidemi Iwata, Hiroji Tajima, Kazuo Kang, Daehee Choi, Ji-Yeob Park, Sue K. Yoo, Keun-Young Maishman, Tom Tapper, William J. Dunning, Alison Shah, Mitul Luben, Robert Brown, Judith Chuen Khor, Chiea Eccles, Diana M. Nevanlinna, Heli Easton, Douglas Humphreys, Keith Liu, Jianjun Hall, Per Czene, Kamila 2q36.3 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy |
title | 2q36.3 is associated with prognosis for oestrogen
receptor-negative breast cancer patients treated with
chemotherapy |
title_full | 2q36.3 is associated with prognosis for oestrogen
receptor-negative breast cancer patients treated with
chemotherapy |
title_fullStr | 2q36.3 is associated with prognosis for oestrogen
receptor-negative breast cancer patients treated with
chemotherapy |
title_full_unstemmed | 2q36.3 is associated with prognosis for oestrogen
receptor-negative breast cancer patients treated with
chemotherapy |
title_short | 2q36.3 is associated with prognosis for oestrogen
receptor-negative breast cancer patients treated with
chemotherapy |
title_sort | 2q36.3 is associated with prognosis for oestrogen
receptor-negative breast cancer patients treated with
chemotherapy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082638/ https://www.ncbi.nlm.nih.gov/pubmed/24937182 http://dx.doi.org/10.1038/ncomms5051 |
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