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Intravoxel incoherent motion MRI: emerging applications for nasopharyngeal carcinoma at the primary site

OBJECTIVES: We compared pure molecular diffusion (D), perfusion-related diffusion (D*), perfusion fraction (f) and apparent diffusion coefficient (ADC) based on intravoxel incoherent motion (IVIM) theory in patients with nasopharyngeal carcinoma (NPC). METHODS: Sixty-five consecutive patients (48 me...

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Autores principales: Zhang, Shui-xing, Jia, Qian-jun, Zhang, Zhong-ping, Liang, Chang-hong, Chen, Wen-bo, Qiu, Qian-hui, Li, He
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082649/
https://www.ncbi.nlm.nih.gov/pubmed/24838795
http://dx.doi.org/10.1007/s00330-014-3203-0
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author Zhang, Shui-xing
Jia, Qian-jun
Zhang, Zhong-ping
Liang, Chang-hong
Chen, Wen-bo
Qiu, Qian-hui
Li, He
author_facet Zhang, Shui-xing
Jia, Qian-jun
Zhang, Zhong-ping
Liang, Chang-hong
Chen, Wen-bo
Qiu, Qian-hui
Li, He
author_sort Zhang, Shui-xing
collection PubMed
description OBJECTIVES: We compared pure molecular diffusion (D), perfusion-related diffusion (D*), perfusion fraction (f) and apparent diffusion coefficient (ADC) based on intravoxel incoherent motion (IVIM) theory in patients with nasopharyngeal carcinoma (NPC). METHODS: Sixty-five consecutive patients (48 men) with suspected NPC were examined using a 3.0-T MR system. Diffusion-weighted imaging (DWI) was performed with 13 b values (range, 0–800 s/mm(2)). We regarded the result of endoscopy and biopsy as the gold standard for detection. D, D* and f were compared between patients with primary NPC and enlarged adenoids. RESULTS: IVIM DWI was successful in 37 of 40 NPC and 23 of 25 enlarged adenoids cases. D (P = 0.001) and f (P < 0.0001) were significantly lower in patients with NPC than in patients with enlarged adenoids, whereas D* was significantly higher (P < 0.0001). However, the ADC was not significantly different between the two groups (P > 0.05). The area under the ROC curve (AUC) for D was 0.849 and was significantly larger than that for ADC (P < 0.05). CONCLUSIONS: IVIM DWI is a feasible technique for investigating primary NPC. D was significantly decreased in primary NPC, and increased D* reflected increased blood vessel generation and parenchymal perfusion in primary NPC. KEY POINTS: • Intravoxel incoherent motion (IVIM) analysis permits separate quantification of diffusion and perfusion. • IVIM DWI is a feasible technique for investigating primary NPC. • IVIM suggests that primary NPC tissue voxels exhibit both perfusion and diffusion.
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spelling pubmed-40826492014-07-10 Intravoxel incoherent motion MRI: emerging applications for nasopharyngeal carcinoma at the primary site Zhang, Shui-xing Jia, Qian-jun Zhang, Zhong-ping Liang, Chang-hong Chen, Wen-bo Qiu, Qian-hui Li, He Eur Radiol Head and Neck OBJECTIVES: We compared pure molecular diffusion (D), perfusion-related diffusion (D*), perfusion fraction (f) and apparent diffusion coefficient (ADC) based on intravoxel incoherent motion (IVIM) theory in patients with nasopharyngeal carcinoma (NPC). METHODS: Sixty-five consecutive patients (48 men) with suspected NPC were examined using a 3.0-T MR system. Diffusion-weighted imaging (DWI) was performed with 13 b values (range, 0–800 s/mm(2)). We regarded the result of endoscopy and biopsy as the gold standard for detection. D, D* and f were compared between patients with primary NPC and enlarged adenoids. RESULTS: IVIM DWI was successful in 37 of 40 NPC and 23 of 25 enlarged adenoids cases. D (P = 0.001) and f (P < 0.0001) were significantly lower in patients with NPC than in patients with enlarged adenoids, whereas D* was significantly higher (P < 0.0001). However, the ADC was not significantly different between the two groups (P > 0.05). The area under the ROC curve (AUC) for D was 0.849 and was significantly larger than that for ADC (P < 0.05). CONCLUSIONS: IVIM DWI is a feasible technique for investigating primary NPC. D was significantly decreased in primary NPC, and increased D* reflected increased blood vessel generation and parenchymal perfusion in primary NPC. KEY POINTS: • Intravoxel incoherent motion (IVIM) analysis permits separate quantification of diffusion and perfusion. • IVIM DWI is a feasible technique for investigating primary NPC. • IVIM suggests that primary NPC tissue voxels exhibit both perfusion and diffusion. Springer Berlin Heidelberg 2014-05-18 2014 /pmc/articles/PMC4082649/ /pubmed/24838795 http://dx.doi.org/10.1007/s00330-014-3203-0 Text en © The Author(s) 2014 https://creativecommons.org/licenses/by-nc/4.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Head and Neck
Zhang, Shui-xing
Jia, Qian-jun
Zhang, Zhong-ping
Liang, Chang-hong
Chen, Wen-bo
Qiu, Qian-hui
Li, He
Intravoxel incoherent motion MRI: emerging applications for nasopharyngeal carcinoma at the primary site
title Intravoxel incoherent motion MRI: emerging applications for nasopharyngeal carcinoma at the primary site
title_full Intravoxel incoherent motion MRI: emerging applications for nasopharyngeal carcinoma at the primary site
title_fullStr Intravoxel incoherent motion MRI: emerging applications for nasopharyngeal carcinoma at the primary site
title_full_unstemmed Intravoxel incoherent motion MRI: emerging applications for nasopharyngeal carcinoma at the primary site
title_short Intravoxel incoherent motion MRI: emerging applications for nasopharyngeal carcinoma at the primary site
title_sort intravoxel incoherent motion mri: emerging applications for nasopharyngeal carcinoma at the primary site
topic Head and Neck
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082649/
https://www.ncbi.nlm.nih.gov/pubmed/24838795
http://dx.doi.org/10.1007/s00330-014-3203-0
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