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Gouty Panniculitis with Ulcerations in a Patient with Multiple Organ Dysfunctions

Gouty panniculitis is a rare manifestation of gout. Clinically, it is characterized by indurated subcutaneous nodules in nonjoint areas. Pathologically, typical characteristic gouty tophi can be seen in subcutaneous tissue. It is postulated that gouty panniculitis develops as a consequence of uric a...

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Autores principales: Wang, Lu, Rose, Crystal, Mellen, Paul, Branam, George, Picken, Maria M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082885/
https://www.ncbi.nlm.nih.gov/pubmed/25018887
http://dx.doi.org/10.1155/2014/320940
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author Wang, Lu
Rose, Crystal
Mellen, Paul
Branam, George
Picken, Maria M.
author_facet Wang, Lu
Rose, Crystal
Mellen, Paul
Branam, George
Picken, Maria M.
author_sort Wang, Lu
collection PubMed
description Gouty panniculitis is a rare manifestation of gout. Clinically, it is characterized by indurated subcutaneous nodules in nonjoint areas. Pathologically, typical characteristic gouty tophi can be seen in subcutaneous tissue. It is postulated that gouty panniculitis develops as a consequence of uric acid accumulation in the body and localized inflammatory changes in subcutaneous tissue. We report a case of a 46-year-old man with 20-year history of gout, who developed multiple subcutaneous nodules over the abdomen and right groin/thigh area over a 2-year period. After a recent episode of congestive heart failure and acute renal failure, the nodules increased in size and the overlying skin became erythematous and ulcerated. Pathologic examination demonstrated typical tophi in the dermis and subcutaneous tissue. A review of the literature yielded fifteen similar cases that had been previously reported. We conclude that gouty panniculitis may be a manifestation of undertreated gout and may be exacerbated by the deterioration of other systemic functions.
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spelling pubmed-40828852014-07-13 Gouty Panniculitis with Ulcerations in a Patient with Multiple Organ Dysfunctions Wang, Lu Rose, Crystal Mellen, Paul Branam, George Picken, Maria M. Case Rep Rheumatol Case Report Gouty panniculitis is a rare manifestation of gout. Clinically, it is characterized by indurated subcutaneous nodules in nonjoint areas. Pathologically, typical characteristic gouty tophi can be seen in subcutaneous tissue. It is postulated that gouty panniculitis develops as a consequence of uric acid accumulation in the body and localized inflammatory changes in subcutaneous tissue. We report a case of a 46-year-old man with 20-year history of gout, who developed multiple subcutaneous nodules over the abdomen and right groin/thigh area over a 2-year period. After a recent episode of congestive heart failure and acute renal failure, the nodules increased in size and the overlying skin became erythematous and ulcerated. Pathologic examination demonstrated typical tophi in the dermis and subcutaneous tissue. A review of the literature yielded fifteen similar cases that had been previously reported. We conclude that gouty panniculitis may be a manifestation of undertreated gout and may be exacerbated by the deterioration of other systemic functions. Hindawi Publishing Corporation 2014 2014-06-15 /pmc/articles/PMC4082885/ /pubmed/25018887 http://dx.doi.org/10.1155/2014/320940 Text en Copyright © 2014 Lu Wang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Wang, Lu
Rose, Crystal
Mellen, Paul
Branam, George
Picken, Maria M.
Gouty Panniculitis with Ulcerations in a Patient with Multiple Organ Dysfunctions
title Gouty Panniculitis with Ulcerations in a Patient with Multiple Organ Dysfunctions
title_full Gouty Panniculitis with Ulcerations in a Patient with Multiple Organ Dysfunctions
title_fullStr Gouty Panniculitis with Ulcerations in a Patient with Multiple Organ Dysfunctions
title_full_unstemmed Gouty Panniculitis with Ulcerations in a Patient with Multiple Organ Dysfunctions
title_short Gouty Panniculitis with Ulcerations in a Patient with Multiple Organ Dysfunctions
title_sort gouty panniculitis with ulcerations in a patient with multiple organ dysfunctions
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082885/
https://www.ncbi.nlm.nih.gov/pubmed/25018887
http://dx.doi.org/10.1155/2014/320940
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