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Gouty Panniculitis with Ulcerations in a Patient with Multiple Organ Dysfunctions
Gouty panniculitis is a rare manifestation of gout. Clinically, it is characterized by indurated subcutaneous nodules in nonjoint areas. Pathologically, typical characteristic gouty tophi can be seen in subcutaneous tissue. It is postulated that gouty panniculitis develops as a consequence of uric a...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082885/ https://www.ncbi.nlm.nih.gov/pubmed/25018887 http://dx.doi.org/10.1155/2014/320940 |
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author | Wang, Lu Rose, Crystal Mellen, Paul Branam, George Picken, Maria M. |
author_facet | Wang, Lu Rose, Crystal Mellen, Paul Branam, George Picken, Maria M. |
author_sort | Wang, Lu |
collection | PubMed |
description | Gouty panniculitis is a rare manifestation of gout. Clinically, it is characterized by indurated subcutaneous nodules in nonjoint areas. Pathologically, typical characteristic gouty tophi can be seen in subcutaneous tissue. It is postulated that gouty panniculitis develops as a consequence of uric acid accumulation in the body and localized inflammatory changes in subcutaneous tissue. We report a case of a 46-year-old man with 20-year history of gout, who developed multiple subcutaneous nodules over the abdomen and right groin/thigh area over a 2-year period. After a recent episode of congestive heart failure and acute renal failure, the nodules increased in size and the overlying skin became erythematous and ulcerated. Pathologic examination demonstrated typical tophi in the dermis and subcutaneous tissue. A review of the literature yielded fifteen similar cases that had been previously reported. We conclude that gouty panniculitis may be a manifestation of undertreated gout and may be exacerbated by the deterioration of other systemic functions. |
format | Online Article Text |
id | pubmed-4082885 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40828852014-07-13 Gouty Panniculitis with Ulcerations in a Patient with Multiple Organ Dysfunctions Wang, Lu Rose, Crystal Mellen, Paul Branam, George Picken, Maria M. Case Rep Rheumatol Case Report Gouty panniculitis is a rare manifestation of gout. Clinically, it is characterized by indurated subcutaneous nodules in nonjoint areas. Pathologically, typical characteristic gouty tophi can be seen in subcutaneous tissue. It is postulated that gouty panniculitis develops as a consequence of uric acid accumulation in the body and localized inflammatory changes in subcutaneous tissue. We report a case of a 46-year-old man with 20-year history of gout, who developed multiple subcutaneous nodules over the abdomen and right groin/thigh area over a 2-year period. After a recent episode of congestive heart failure and acute renal failure, the nodules increased in size and the overlying skin became erythematous and ulcerated. Pathologic examination demonstrated typical tophi in the dermis and subcutaneous tissue. A review of the literature yielded fifteen similar cases that had been previously reported. We conclude that gouty panniculitis may be a manifestation of undertreated gout and may be exacerbated by the deterioration of other systemic functions. Hindawi Publishing Corporation 2014 2014-06-15 /pmc/articles/PMC4082885/ /pubmed/25018887 http://dx.doi.org/10.1155/2014/320940 Text en Copyright © 2014 Lu Wang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Wang, Lu Rose, Crystal Mellen, Paul Branam, George Picken, Maria M. Gouty Panniculitis with Ulcerations in a Patient with Multiple Organ Dysfunctions |
title | Gouty Panniculitis with Ulcerations in a Patient with Multiple Organ Dysfunctions |
title_full | Gouty Panniculitis with Ulcerations in a Patient with Multiple Organ Dysfunctions |
title_fullStr | Gouty Panniculitis with Ulcerations in a Patient with Multiple Organ Dysfunctions |
title_full_unstemmed | Gouty Panniculitis with Ulcerations in a Patient with Multiple Organ Dysfunctions |
title_short | Gouty Panniculitis with Ulcerations in a Patient with Multiple Organ Dysfunctions |
title_sort | gouty panniculitis with ulcerations in a patient with multiple organ dysfunctions |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082885/ https://www.ncbi.nlm.nih.gov/pubmed/25018887 http://dx.doi.org/10.1155/2014/320940 |
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