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Efficacy and Pharmacologic Data of Second-Generation Tyrosine Kinase Inhibitor Nilotinib in BCR-ABL-Positive Leukemia Patients with Central Nervous System Relapse after Allogeneic Stem Cell Transplantation

Central nervous system (CNS) involvement is a severe complication of BCR-ABL-positive leukemia after allogenic stem cell transplantation (alloSCT) associated with fatal outcome. Although second-generation tyrosine-kinase inhibitors (TKI) such as nilotinib have shown activity in systemic BCR-ABL(+) d...

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Detalles Bibliográficos
Autores principales:	Reinwald, Mark, Schleyer, Eberhard, Kiewe, Philipp, Blau, Igor Wolfgang, Burmeister, Thomas, Pursche, Stefan, Neumann, Martin, Notter, Michael, Thiel, Eckhard, Hofmann, Wolf-Karsten, Kolb, Hans-Jochem, Burdach, Stefan, Bender, Hans-Ulrich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2014
Materias:	Clinical Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4082894/ https://www.ncbi.nlm.nih.gov/pubmed/25025064 http://dx.doi.org/10.1155/2014/637059

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