Activation of GPR40 attenuates chronic inflammation induced impact on pancreatic β-cells health and function

BACKGROUND: Chronic inflammation-mediated β-cell apoptosis is known to decrease β-cell mass in diabetes leading to reduced insulin secretion. Exposure to pro-inflammatory cytokines can stimulate apoptosis in pancreatic β-cells. The G protein coupled receptor 40 (GPR40) is implicated for glucose indu...

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Detalles Bibliográficos
Autores principales: Verma, Mahesh Kumar, Sadasivuni, Manoj Kumar, Yateesh, Aggunda N, Neelima, Korrapati, Mrudula, Srikanth, Reddy, Madhusudhan, Smitha, Rachapalli, Biswas, Sanghamitra, Chandravanshi, Bhawna, Pallavi, Puttrevana M, Oommen, Anup M, Jagannath, Madanahalli R, Somesh, Baggavalli B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083038/
https://www.ncbi.nlm.nih.gov/pubmed/24974801
http://dx.doi.org/10.1186/1471-2121-15-24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083038/
https://www.ncbi.nlm.nih.gov/pubmed/24974801
http://dx.doi.org/10.1186/1471-2121-15-24

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