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LINEing germ and embryonic stem cells’ silencing of retrotransposons

Almost half of our genome is occupied by transposable elements. Although most of them are inactive, one type of non-long terminal repeat (LTR) retrotransposon, long interspersed nuclear element 1 (LINE1), is capable of retrotransposition. Two studies in this issue, Pezic and colleagues (pp. 1410–142...

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Detalles Bibliográficos
Autores principales: Ishiuchi, Takashi, Torres-Padilla, Maria-Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083083/
https://www.ncbi.nlm.nih.gov/pubmed/24990961
http://dx.doi.org/10.1101/gad.246462.114
Descripción
Sumario:Almost half of our genome is occupied by transposable elements. Although most of them are inactive, one type of non-long terminal repeat (LTR) retrotransposon, long interspersed nuclear element 1 (LINE1), is capable of retrotransposition. Two studies in this issue, Pezic and colleagues (pp. 1410–1428) and Castro-Diaz and colleagues (pp. 1397–1409), provide novel insight into the regulation of LINE1s in human embryonic stem cells and mouse germ cells and shed new light on the conservation of complex mechanisms to ensure silencing of transposable elements in mammals.