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LINEing germ and embryonic stem cells’ silencing of retrotransposons
Almost half of our genome is occupied by transposable elements. Although most of them are inactive, one type of non-long terminal repeat (LTR) retrotransposon, long interspersed nuclear element 1 (LINE1), is capable of retrotransposition. Two studies in this issue, Pezic and colleagues (pp. 1410–142...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083083/ https://www.ncbi.nlm.nih.gov/pubmed/24990961 http://dx.doi.org/10.1101/gad.246462.114 |
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author | Ishiuchi, Takashi Torres-Padilla, Maria-Elena |
author_facet | Ishiuchi, Takashi Torres-Padilla, Maria-Elena |
author_sort | Ishiuchi, Takashi |
collection | PubMed |
description | Almost half of our genome is occupied by transposable elements. Although most of them are inactive, one type of non-long terminal repeat (LTR) retrotransposon, long interspersed nuclear element 1 (LINE1), is capable of retrotransposition. Two studies in this issue, Pezic and colleagues (pp. 1410–1428) and Castro-Diaz and colleagues (pp. 1397–1409), provide novel insight into the regulation of LINE1s in human embryonic stem cells and mouse germ cells and shed new light on the conservation of complex mechanisms to ensure silencing of transposable elements in mammals. |
format | Online Article Text |
id | pubmed-4083083 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-40830832015-01-01 LINEing germ and embryonic stem cells’ silencing of retrotransposons Ishiuchi, Takashi Torres-Padilla, Maria-Elena Genes Dev Perspective Almost half of our genome is occupied by transposable elements. Although most of them are inactive, one type of non-long terminal repeat (LTR) retrotransposon, long interspersed nuclear element 1 (LINE1), is capable of retrotransposition. Two studies in this issue, Pezic and colleagues (pp. 1410–1428) and Castro-Diaz and colleagues (pp. 1397–1409), provide novel insight into the regulation of LINE1s in human embryonic stem cells and mouse germ cells and shed new light on the conservation of complex mechanisms to ensure silencing of transposable elements in mammals. Cold Spring Harbor Laboratory Press 2014-07-01 /pmc/articles/PMC4083083/ /pubmed/24990961 http://dx.doi.org/10.1101/gad.246462.114 Text en © 2014 Ishiuchi and Torres-Padilla; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Perspective Ishiuchi, Takashi Torres-Padilla, Maria-Elena LINEing germ and embryonic stem cells’ silencing of retrotransposons |
title | LINEing germ and embryonic stem cells’ silencing of retrotransposons |
title_full | LINEing germ and embryonic stem cells’ silencing of retrotransposons |
title_fullStr | LINEing germ and embryonic stem cells’ silencing of retrotransposons |
title_full_unstemmed | LINEing germ and embryonic stem cells’ silencing of retrotransposons |
title_short | LINEing germ and embryonic stem cells’ silencing of retrotransposons |
title_sort | lineing germ and embryonic stem cells’ silencing of retrotransposons |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083083/ https://www.ncbi.nlm.nih.gov/pubmed/24990961 http://dx.doi.org/10.1101/gad.246462.114 |
work_keys_str_mv | AT ishiuchitakashi lineinggermandembryonicstemcellssilencingofretrotransposons AT torrespadillamariaelena lineinggermandembryonicstemcellssilencingofretrotransposons |