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LINEing germ and embryonic stem cells’ silencing of retrotransposons

Almost half of our genome is occupied by transposable elements. Although most of them are inactive, one type of non-long terminal repeat (LTR) retrotransposon, long interspersed nuclear element 1 (LINE1), is capable of retrotransposition. Two studies in this issue, Pezic and colleagues (pp. 1410–142...

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Detalles Bibliográficos
Autores principales: Ishiuchi, Takashi, Torres-Padilla, Maria-Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083083/
https://www.ncbi.nlm.nih.gov/pubmed/24990961
http://dx.doi.org/10.1101/gad.246462.114
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author Ishiuchi, Takashi
Torres-Padilla, Maria-Elena
author_facet Ishiuchi, Takashi
Torres-Padilla, Maria-Elena
author_sort Ishiuchi, Takashi
collection PubMed
description Almost half of our genome is occupied by transposable elements. Although most of them are inactive, one type of non-long terminal repeat (LTR) retrotransposon, long interspersed nuclear element 1 (LINE1), is capable of retrotransposition. Two studies in this issue, Pezic and colleagues (pp. 1410–1428) and Castro-Diaz and colleagues (pp. 1397–1409), provide novel insight into the regulation of LINE1s in human embryonic stem cells and mouse germ cells and shed new light on the conservation of complex mechanisms to ensure silencing of transposable elements in mammals.
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spelling pubmed-40830832015-01-01 LINEing germ and embryonic stem cells’ silencing of retrotransposons Ishiuchi, Takashi Torres-Padilla, Maria-Elena Genes Dev Perspective Almost half of our genome is occupied by transposable elements. Although most of them are inactive, one type of non-long terminal repeat (LTR) retrotransposon, long interspersed nuclear element 1 (LINE1), is capable of retrotransposition. Two studies in this issue, Pezic and colleagues (pp. 1410–1428) and Castro-Diaz and colleagues (pp. 1397–1409), provide novel insight into the regulation of LINE1s in human embryonic stem cells and mouse germ cells and shed new light on the conservation of complex mechanisms to ensure silencing of transposable elements in mammals. Cold Spring Harbor Laboratory Press 2014-07-01 /pmc/articles/PMC4083083/ /pubmed/24990961 http://dx.doi.org/10.1101/gad.246462.114 Text en © 2014 Ishiuchi and Torres-Padilla; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Perspective
Ishiuchi, Takashi
Torres-Padilla, Maria-Elena
LINEing germ and embryonic stem cells’ silencing of retrotransposons
title LINEing germ and embryonic stem cells’ silencing of retrotransposons
title_full LINEing germ and embryonic stem cells’ silencing of retrotransposons
title_fullStr LINEing germ and embryonic stem cells’ silencing of retrotransposons
title_full_unstemmed LINEing germ and embryonic stem cells’ silencing of retrotransposons
title_short LINEing germ and embryonic stem cells’ silencing of retrotransposons
title_sort lineing germ and embryonic stem cells’ silencing of retrotransposons
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083083/
https://www.ncbi.nlm.nih.gov/pubmed/24990961
http://dx.doi.org/10.1101/gad.246462.114
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