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SUMOylation of ATRIP potentiates DNA damage signaling by boosting multiple protein interactions in the ATR pathway

The ATR (ATM [ataxia telangiectasia-mutated]- and Rad3-related) checkpoint is a crucial DNA damage signaling pathway. While the ATR pathway is known to transmit DNA damage signals through the ATR–Chk1 kinase cascade, whether post-translational modifications other than phosphorylation are important f...

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Detalles Bibliográficos
Autores principales:	Wu, Ching-Shyi, Ouyang, Jian, Mori, Eiichiro, Nguyen, Hai Dang, Maréchal, Alexandre, Hallet, Alexander, Chen, David J., Zou, Lee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083090/ https://www.ncbi.nlm.nih.gov/pubmed/24990965 http://dx.doi.org/10.1101/gad.238535.114

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