Enhanced Prediction of Src Homology 2 (SH2) Domain Binding Potentials Using a Fluorescence Polarization-derived c-Met, c-Kit, ErbB, and Androgen Receptor Interactome

Many human diseases are associated with aberrant regulation of phosphoprotein signaling networks. Src homology 2 (SH2) domains represent the major class of protein domains in metazoans that interact with proteins phosphorylated on the amino acid residue tyrosine. Although current SH2 domain predicti...

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Detalles Bibliográficos
Autores principales: Leung, Kin K., Hause, Ronald J., Barkinge, John L., Ciaccio, Mark F., Chuu, Chih-Pin, Jones, Richard B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083110/
https://www.ncbi.nlm.nih.gov/pubmed/24728074
http://dx.doi.org/10.1074/mcp.M113.034876

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