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Bone density in transfusion dependent thalassemia patients in Urmia, Iran
BACKGROUND: Patients with thalassemia major and intermedia are susceptible to osteopenia and osteoporosis. The mechanism of osteoporosis in these patients is multifactorial. Transfusion related iron overload in endocrine organs leads to impaired growth hormone secretion, diabetes mellitus, hypothyro...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Shahid Sadoughi University of Medical Sciences
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083203/ https://www.ncbi.nlm.nih.gov/pubmed/25002928 |
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author | Valizadeh, N Farrokhi, F Alinejad, V Said Mardani, SM Valizadeh, N Hejazi, S Noroozi, M |
author_facet | Valizadeh, N Farrokhi, F Alinejad, V Said Mardani, SM Valizadeh, N Hejazi, S Noroozi, M |
author_sort | Valizadeh, N |
collection | PubMed |
description | BACKGROUND: Patients with thalassemia major and intermedia are susceptible to osteopenia and osteoporosis. The mechanism of osteoporosis in these patients is multifactorial. Transfusion related iron overload in endocrine organs leads to impaired growth hormone secretion, diabetes mellitus, hypothyroidism, hypoparathyroidism, lack of sex steroids and vitamin D deficiency that contribute to impairment in achieving an adequate bone mass .The aim of this study was assessment of frequency of bone loss in patients with thalassemia major and intermedia in Urmia City of West Azerbaijan, Iran MATERIALS AND METHODS: In this cross sectional descriptive study,10 patients (lower than 18 y/o)with transfusion dependent thalassemia attending to Motahari and Emam Khomeini hospitals in Urmia city of Iran were enrolled and scanned for Bone Mineral Density (BMD) starting at around 10 years old. RESULTS: Tenatients (6 male and 4 female) with transfusion dependent thalassemia (β-thalassemia major and intermedia) aged 13to 17 years in Urmia city of Iran were enrolled. Mean age of patients was 15.1±.37year old. Among them, 8 patients (80%)had low BMD and2 of them (20%) had normal BMD in lumbar spine. Only 30% of patients had low BMD in the neck of femur. CONCLUSION: We should perform annual BMD in patients with thalassemia major and intermedia and hemoglobin H disease in age of higher than 8 year old and treat low BMD with administration of bisphosphonate, calcium and vitamin D supplements. Medical consultation with a rheumatologist and /or an endocrinologist should be performed in these patients. Changing lifestyle with mild daily exercise, adequate calcium containing foods, avoiding heavy activities, stop smoking, iron chelation therapy in adequate dosage, early diagnosis and treatment of endocrine insufficiency and regular blood transfusions can help to achieve an optimal bone density in these patients. |
format | Online Article Text |
id | pubmed-4083203 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Shahid Sadoughi University of Medical Sciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-40832032014-07-07 Bone density in transfusion dependent thalassemia patients in Urmia, Iran Valizadeh, N Farrokhi, F Alinejad, V Said Mardani, SM Valizadeh, N Hejazi, S Noroozi, M Iran J Ped Hematol Oncol Original Article BACKGROUND: Patients with thalassemia major and intermedia are susceptible to osteopenia and osteoporosis. The mechanism of osteoporosis in these patients is multifactorial. Transfusion related iron overload in endocrine organs leads to impaired growth hormone secretion, diabetes mellitus, hypothyroidism, hypoparathyroidism, lack of sex steroids and vitamin D deficiency that contribute to impairment in achieving an adequate bone mass .The aim of this study was assessment of frequency of bone loss in patients with thalassemia major and intermedia in Urmia City of West Azerbaijan, Iran MATERIALS AND METHODS: In this cross sectional descriptive study,10 patients (lower than 18 y/o)with transfusion dependent thalassemia attending to Motahari and Emam Khomeini hospitals in Urmia city of Iran were enrolled and scanned for Bone Mineral Density (BMD) starting at around 10 years old. RESULTS: Tenatients (6 male and 4 female) with transfusion dependent thalassemia (β-thalassemia major and intermedia) aged 13to 17 years in Urmia city of Iran were enrolled. Mean age of patients was 15.1±.37year old. Among them, 8 patients (80%)had low BMD and2 of them (20%) had normal BMD in lumbar spine. Only 30% of patients had low BMD in the neck of femur. CONCLUSION: We should perform annual BMD in patients with thalassemia major and intermedia and hemoglobin H disease in age of higher than 8 year old and treat low BMD with administration of bisphosphonate, calcium and vitamin D supplements. Medical consultation with a rheumatologist and /or an endocrinologist should be performed in these patients. Changing lifestyle with mild daily exercise, adequate calcium containing foods, avoiding heavy activities, stop smoking, iron chelation therapy in adequate dosage, early diagnosis and treatment of endocrine insufficiency and regular blood transfusions can help to achieve an optimal bone density in these patients. Shahid Sadoughi University of Medical Sciences 2014 2014-04-20 /pmc/articles/PMC4083203/ /pubmed/25002928 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Valizadeh, N Farrokhi, F Alinejad, V Said Mardani, SM Valizadeh, N Hejazi, S Noroozi, M Bone density in transfusion dependent thalassemia patients in Urmia, Iran |
title | Bone density in transfusion dependent thalassemia patients in Urmia, Iran |
title_full | Bone density in transfusion dependent thalassemia patients in Urmia, Iran |
title_fullStr | Bone density in transfusion dependent thalassemia patients in Urmia, Iran |
title_full_unstemmed | Bone density in transfusion dependent thalassemia patients in Urmia, Iran |
title_short | Bone density in transfusion dependent thalassemia patients in Urmia, Iran |
title_sort | bone density in transfusion dependent thalassemia patients in urmia, iran |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083203/ https://www.ncbi.nlm.nih.gov/pubmed/25002928 |
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