Cargando…

The Gene-Gene Interaction of INSIG-SCAP-SREBP Pathway on the Risk of Obesity in Chinese Children

Background. Childhood obesity has become a global public health problem in recent years. This study aimed to explore the association of genetic variants in INSIG-SCAP-SREBP pathway with obesity in Chinese children. Methods. A case-control study was conducted, including 705 obese cases and 1,325 nono...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Fang-Hong, Song, Jie-Yun, Shang, Xiao-Rui, Meng, Xiang-Rui, Ma, Jun, Wang, Hai-Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083216/ https://www.ncbi.nlm.nih.gov/pubmed/25028659 http://dx.doi.org/10.1155/2014/538564

Ejemplares similares

Ammonia stimulates SCAP/Insig dissociation and SREBP-1 activation to promote lipogenesis and tumor growth
por: Cheng, Chunming, et al.
Publicado: (2022)

Epithelial SCAP/INSIG/SREBP Signaling Regulates Multiple Biological Processes during Perinatal Lung Maturation
por: Bridges, James P., et al.
Publicado: (2014)

The role of cholesterol binding in the control of cholesterol by the Scap–Insig system
por: Lee, Anthony G.
Publicado: (2022)

The SCAP/SREBP Pathway: A Mediator of Hepatic Steatosis
por: Moon, Young-Ah
Publicado: (2017)

GP73 regulates Hepatic Steatosis by enhancing SCAP-SREBPs interaction
por: Yang, Xiaoli, et al.
Publicado: (2017)

Cholesterol Contributes to Diabetic Nephropathy through SCAP-SREBP-2 Pathway
por: Sun, Hong, et al.
Publicado: (2013)

Genetic variations in sterol regulatory element binding protein cleavage-activating protein (SCAP) are associated with blood pressure in overweight/obese Chinese children
por: Yang, Yi-De, et al.
Publicado: (2017)

Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization
por: Gong, Xin, et al.
Publicado: (2016)

Correction: Genetic variations in sterol regulatory element binding protein cleavage-activating protein (SCAP) are associated with blood pressure in overweight/obese Chinese children
por: Yang, Yi-De, et al.
Publicado: (2019)

Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis
por: Tsushima, Hidetoshi, et al.
Publicado: (2018)

Overexpression of Insig-1 protects β cell against glucolipotoxicity via SREBP-1c
por: Chen, Ke, et al.
Publicado: (2011)

Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis
por: Kawamura, Satoshi, et al.
Publicado: (2022)

Hypomorphic ASGR1 modulates lipid homeostasis via INSIG1-mediated SREBP signaling suppression
por: Xu, Yingying, et al.
Publicado: (2021)

Accumulation of Advanced Glycation End-Products and Activation of the SCAP/SREBP Lipogenetic Pathway Occur in Diet-Induced Obese Mouse Skeletal Muscle
por: Mastrocola, Raffaella, et al.
Publicado: (2015)

PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus
por: Xu, Daqian, et al.
Publicado: (2015)

CD36 promotes de novo lipogenesis in hepatocytes through INSIG2-dependent SREBP1 processing
por: Zeng, Han, et al.
Publicado: (2021)

INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese
por: Hotta, Kikuko, et al.
Publicado: (2008)

Effect of Tetramethylpyrazine on Atherosclerosis and SCAP/SREBP-1c Signaling Pathway in ApoE(−/−) Mice Fed with a High-Fat Diet
por: Zhang, Ying, et al.
Publicado: (2017)

The Chromatin Remodeling Protein BRG1 Regulates SREBP Maturation by Activating SCAP Transcription in Hepatocytes
por: Kong, Ming, et al.
Publicado: (2021)

Quercetin improves lipid metabolism via SCAP-SREBP2-LDLr signaling pathway in early stage diabetic nephropathy
por: Jiang, Xiyuan, et al.
Publicado: (2019)

PPARα-dependent Insig2a overexpression inhibits SREBP-1c processing during fasting
por: Lee, Jae-Ho, et al.
Publicado: (2017)

Adaptive Changes of the Insig1/SREBP1/SCD1 Set Point Help Adipose Tissue to Cope With Increased Storage Demands of Obesity
por: Carobbio, Stefania, et al.
Publicado: (2013)

Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition
por: Gong, Xin, et al.
Publicado: (2015)

CRTC2 modulates hepatic SREBP1c cleavage by controlling Insig2a expression during fasting
por: Zhang, Yuanyuan, et al.
Publicado: (2018)

Long-Term Disturbed Expression and DNA Methylation of SCAP/SREBP Signaling in the Mouse Lung From Assisted Reproductive Technologies
por: Le, Fang, et al.
Publicado: (2021)

Anti-Inflammatory Effects of Ang-(1-7) in Ameliorating HFD-Induced Renal Injury through LDLr-SREBP2-SCAP Pathway
por: Zheng, Yaning, et al.
Publicado: (2015)

LncGSAR Controls Ovarian Granulosa Cell Steroidogenesis via Sponging MiR-125b to Activate SCAP/SREBP Pathway
por: Wang, Yong, et al.
Publicado: (2022)

Cideb controls sterol‐regulated ER export of SREBP/SCAP by promoting cargo loading at ER exit sites
por: Su, Lu, et al.
Publicado: (2019)

RA-XII Suppresses the Development and Growth of Liver Cancer by Inhibition of Lipogenesis via SCAP-dependent SREBP Supression
por: Guo, Di, et al.
Publicado: (2019)

Comparison of In Vivo Effects of Insulin on SREBP-1c Activation and INSIG-1/2 in Rat Liver and Human and Rat Adipose Tissue
por: Boden, Guenther, et al.
Publicado: (2013)

Insulin-induced genes INSIG1 and INSIG2 mediate oxysterol-dependent activation of the PERK–eIF2α–ATF4 axis
por: Watanabe, Yuichi, et al.
Publicado: (2021)

Common Genetic Variant of INSIG2 Gene rs7566605 Polymorphism Is Associated with Severe Obesity in North India
por: Prakash, Jai, et al.
Publicado: (2017)

A novel protein encoded by circINSIG1 reprograms cholesterol metabolism by promoting the ubiquitin-dependent degradation of INSIG1 in colorectal cancer
por: Xiong, Li, et al.
Publicado: (2023)

Pig fatness in relation to FASN and INSIG2 genes polymorphism and their transcript level
por: Grzes, Maria, et al.
Publicado: (2016)

Associations of the SREBF2 Gene and INSIG2 Polymorphisms with Obesity and Dyslipidemia in Thai Psychotic Disorder Patients Treated with Risperidone
por: Vanwong, Natchaya, et al.
Publicado: (2021)

Unripe Rubus coreanus Miquel Extract Containing Ellagic Acid Regulates AMPK, SREBP-2, HMGCR, and INSIG-1 Signaling and Cholesterol Metabolism In Vitro and In Vivo
por: Lee, Ki Hoon, et al.
Publicado: (2020)

Association of an INSIG2 obesity allele with cardiovascular phenotypes is gender and age dependent
por: Skelding, Kimberly A, et al.
Publicado: (2010)

Association analyses of the INSIG2 polymorphism in the obesity and cholesterol levels of Korean populations
por: Cha, Seongwon, et al.
Publicado: (2009)

Association of genetic variations in the lipid regulatory pathway genes FBXW7 and SREBPs with coronary artery disease among Han Chinese and Uygur Chinese populations in Xinjiang, China
por: Abudesimu, Asiya, et al.
Publicado: (2017)

Identification of Novel Genes and Pathways Regulating SREBP Transcriptional Activity
por: Chatterjee, Sandipan, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_sppssdqsq1ure2hpfs83s2s9q0