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Early Diagnosis of Leptospirosis
A 25-years old man from Zagreb, Croatia, was admitted to the University Hospital for Infectious Diseases four days after the onset of symptoms such as fever, intense pain in the calves and anuria. The patient owned a rabbit and, before the onset of the disease, repaired some rubber pipes damaged by...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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PAGEPress Publications, Pavia, Italy
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083297/ https://www.ncbi.nlm.nih.gov/pubmed/25002958 http://dx.doi.org/10.4081/idr.2014.5156 |
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author | Babic-Erceg, Andrea Karlovic-Martinkovic, Diana Santini, Marija Persic, Zdenka Vilibic-Cavlek, Tatjana |
author_facet | Babic-Erceg, Andrea Karlovic-Martinkovic, Diana Santini, Marija Persic, Zdenka Vilibic-Cavlek, Tatjana |
author_sort | Babic-Erceg, Andrea |
collection | PubMed |
description | A 25-years old man from Zagreb, Croatia, was admitted to the University Hospital for Infectious Diseases four days after the onset of symptoms such as fever, intense pain in the calves and anuria. The patient owned a rabbit and, before the onset of the disease, repaired some rubber pipes damaged by rodents. At admission, he had a severe clinical picture with fever, hypotension, jaundice, immobility, and pain in leg muscles. Treatment with ceftriaxone was initiated in combination with volume restitution. Renal failure soon ensued. Consequently continuous venovenous hemodiaphiltration therapy was performed. Due to acute respiratory distress syndrome, the patient was mechanically ventilated. The patient’s condition gradually improved and he recovered fully from multi-organ failure. Diagnosis was confirmed by a microscopic agglutination test (MAT) covering 15 leptospira serovars and real-time polymerase-chain reaction (PCR). The first serum sample taken on day 6 tested negative for leptospira, while PCR showed positive results for leptospiral DNA. The second serum sample taken on day 13 tested positive for serovar Canicola serogroup Canicola, serovar Patoc, serovar Grippotyphosa serogroup Grippotyphosa and serovar Tarassovi serogroup Tarassovi (titre 4000, 4000, 1000 and 2000, respectively), while PCR was negative. This report highlights the benefits of combining MAT and PCR methods in early diagnosis of leptospirosis. |
format | Online Article Text |
id | pubmed-4083297 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | PAGEPress Publications, Pavia, Italy |
record_format | MEDLINE/PubMed |
spelling | pubmed-40832972014-07-07 Early Diagnosis of Leptospirosis Babic-Erceg, Andrea Karlovic-Martinkovic, Diana Santini, Marija Persic, Zdenka Vilibic-Cavlek, Tatjana Infect Dis Rep Case Report A 25-years old man from Zagreb, Croatia, was admitted to the University Hospital for Infectious Diseases four days after the onset of symptoms such as fever, intense pain in the calves and anuria. The patient owned a rabbit and, before the onset of the disease, repaired some rubber pipes damaged by rodents. At admission, he had a severe clinical picture with fever, hypotension, jaundice, immobility, and pain in leg muscles. Treatment with ceftriaxone was initiated in combination with volume restitution. Renal failure soon ensued. Consequently continuous venovenous hemodiaphiltration therapy was performed. Due to acute respiratory distress syndrome, the patient was mechanically ventilated. The patient’s condition gradually improved and he recovered fully from multi-organ failure. Diagnosis was confirmed by a microscopic agglutination test (MAT) covering 15 leptospira serovars and real-time polymerase-chain reaction (PCR). The first serum sample taken on day 6 tested negative for leptospira, while PCR showed positive results for leptospiral DNA. The second serum sample taken on day 13 tested positive for serovar Canicola serogroup Canicola, serovar Patoc, serovar Grippotyphosa serogroup Grippotyphosa and serovar Tarassovi serogroup Tarassovi (titre 4000, 4000, 1000 and 2000, respectively), while PCR was negative. This report highlights the benefits of combining MAT and PCR methods in early diagnosis of leptospirosis. PAGEPress Publications, Pavia, Italy 2014-06-24 /pmc/articles/PMC4083297/ /pubmed/25002958 http://dx.doi.org/10.4081/idr.2014.5156 Text en ©Copyright A. Babic-Erceg et al. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Babic-Erceg, Andrea Karlovic-Martinkovic, Diana Santini, Marija Persic, Zdenka Vilibic-Cavlek, Tatjana Early Diagnosis of Leptospirosis |
title | Early Diagnosis of Leptospirosis |
title_full | Early Diagnosis of Leptospirosis |
title_fullStr | Early Diagnosis of Leptospirosis |
title_full_unstemmed | Early Diagnosis of Leptospirosis |
title_short | Early Diagnosis of Leptospirosis |
title_sort | early diagnosis of leptospirosis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083297/ https://www.ncbi.nlm.nih.gov/pubmed/25002958 http://dx.doi.org/10.4081/idr.2014.5156 |
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