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Patient-reported urinary incontinence following stereotactic body radiation therapy (SBRT) for clinically localized prostate cancer

PURPOSE: Urinary incontinence (UI) following prostate radiotherapy is a rare toxicity that adversely affects a patient’s quality of life. This study sought to evaluate the incidence of UI following stereotactic body radiation therapy (SBRT) for prostate cancer. METHODS: Between February, 2008 and Oc...

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Autores principales: Chen, Leonard N, Suy, Simeng, Wang, Hongkun, Bhagat, Aditi, Woo, Jennifer A, Moures, Rudy A, Kim, Joy S, Yung, Thomas M, Lei, Siyuan, Collins, Brian T, Kowalczyk, Keith, Dritschilo, Anatoly, Lynch, John H, Collins, Sean P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083362/
https://www.ncbi.nlm.nih.gov/pubmed/24966110
http://dx.doi.org/10.1186/1748-717X-9-148
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author Chen, Leonard N
Suy, Simeng
Wang, Hongkun
Bhagat, Aditi
Woo, Jennifer A
Moures, Rudy A
Kim, Joy S
Yung, Thomas M
Lei, Siyuan
Collins, Brian T
Kowalczyk, Keith
Dritschilo, Anatoly
Lynch, John H
Collins, Sean P
author_facet Chen, Leonard N
Suy, Simeng
Wang, Hongkun
Bhagat, Aditi
Woo, Jennifer A
Moures, Rudy A
Kim, Joy S
Yung, Thomas M
Lei, Siyuan
Collins, Brian T
Kowalczyk, Keith
Dritschilo, Anatoly
Lynch, John H
Collins, Sean P
author_sort Chen, Leonard N
collection PubMed
description PURPOSE: Urinary incontinence (UI) following prostate radiotherapy is a rare toxicity that adversely affects a patient’s quality of life. This study sought to evaluate the incidence of UI following stereotactic body radiation therapy (SBRT) for prostate cancer. METHODS: Between February, 2008 and October, 2010, 204 men with clinically localized prostate cancer were treated definitively with SBRT at Georgetown University Hospital. Patients were treated to 35–36.25 Gray (Gy) in 5 fractions delivered with the CyberKnife (Accuray). UI was assessed via the Expanded Prostate Index Composite (EPIC)-26. RESULTS: Baseline UI was common with 4.4%, 1.0% and 3.4% of patients reporting leaking > 1 time per day, frequent dribbling and pad usage, respectively. Three year post treatment, 5.7%, 6.4% and 10.8% of patients reported UI based on leaking > 1 time per day, frequent dribbling and pad usage, respectively. Average EPIC UI summary scores showed an acute transient decline at one month post-SBRT then a second a gradual decline over the next three years. The proportion of men feeling that their UI was a moderate to big problem increased from 1% at baseline to 6.4% at three years post-SBRT. CONCLUSIONS: Prostate SBRT was well tolerated with UI rates comparable to conventionally fractionated radiotherapy and brachytherapy. More than 90% of men who were pad-free prior to treatment remained pad-free three years following treatment. Less than 10% of men felt post-treatment UI was a moderate to big problem at any time point following treatment. Longer term follow-up is needed to confirm late effects.
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spelling pubmed-40833622014-07-08 Patient-reported urinary incontinence following stereotactic body radiation therapy (SBRT) for clinically localized prostate cancer Chen, Leonard N Suy, Simeng Wang, Hongkun Bhagat, Aditi Woo, Jennifer A Moures, Rudy A Kim, Joy S Yung, Thomas M Lei, Siyuan Collins, Brian T Kowalczyk, Keith Dritschilo, Anatoly Lynch, John H Collins, Sean P Radiat Oncol Research PURPOSE: Urinary incontinence (UI) following prostate radiotherapy is a rare toxicity that adversely affects a patient’s quality of life. This study sought to evaluate the incidence of UI following stereotactic body radiation therapy (SBRT) for prostate cancer. METHODS: Between February, 2008 and October, 2010, 204 men with clinically localized prostate cancer were treated definitively with SBRT at Georgetown University Hospital. Patients were treated to 35–36.25 Gray (Gy) in 5 fractions delivered with the CyberKnife (Accuray). UI was assessed via the Expanded Prostate Index Composite (EPIC)-26. RESULTS: Baseline UI was common with 4.4%, 1.0% and 3.4% of patients reporting leaking > 1 time per day, frequent dribbling and pad usage, respectively. Three year post treatment, 5.7%, 6.4% and 10.8% of patients reported UI based on leaking > 1 time per day, frequent dribbling and pad usage, respectively. Average EPIC UI summary scores showed an acute transient decline at one month post-SBRT then a second a gradual decline over the next three years. The proportion of men feeling that their UI was a moderate to big problem increased from 1% at baseline to 6.4% at three years post-SBRT. CONCLUSIONS: Prostate SBRT was well tolerated with UI rates comparable to conventionally fractionated radiotherapy and brachytherapy. More than 90% of men who were pad-free prior to treatment remained pad-free three years following treatment. Less than 10% of men felt post-treatment UI was a moderate to big problem at any time point following treatment. Longer term follow-up is needed to confirm late effects. BioMed Central 2014-06-26 /pmc/articles/PMC4083362/ /pubmed/24966110 http://dx.doi.org/10.1186/1748-717X-9-148 Text en Copyright © 2014 Chen et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Chen, Leonard N
Suy, Simeng
Wang, Hongkun
Bhagat, Aditi
Woo, Jennifer A
Moures, Rudy A
Kim, Joy S
Yung, Thomas M
Lei, Siyuan
Collins, Brian T
Kowalczyk, Keith
Dritschilo, Anatoly
Lynch, John H
Collins, Sean P
Patient-reported urinary incontinence following stereotactic body radiation therapy (SBRT) for clinically localized prostate cancer
title Patient-reported urinary incontinence following stereotactic body radiation therapy (SBRT) for clinically localized prostate cancer
title_full Patient-reported urinary incontinence following stereotactic body radiation therapy (SBRT) for clinically localized prostate cancer
title_fullStr Patient-reported urinary incontinence following stereotactic body radiation therapy (SBRT) for clinically localized prostate cancer
title_full_unstemmed Patient-reported urinary incontinence following stereotactic body radiation therapy (SBRT) for clinically localized prostate cancer
title_short Patient-reported urinary incontinence following stereotactic body radiation therapy (SBRT) for clinically localized prostate cancer
title_sort patient-reported urinary incontinence following stereotactic body radiation therapy (sbrt) for clinically localized prostate cancer
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083362/
https://www.ncbi.nlm.nih.gov/pubmed/24966110
http://dx.doi.org/10.1186/1748-717X-9-148
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