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Meta-analysis of molecular imaging of serotonin transporters in major depression

The success of serotonin-selective reuptake inhibitors has lent support to the monoamine theory of major depressive disorder (MDD). This issue has been addressed in a number of molecular imaging studies by positron emission tomography or single-photon emission computed tomography of serotonin reupta...

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Autores principales: Gryglewski, Gregor, Lanzenberger, Rupert, Kranz, Georg S, Cumming, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083395/
https://www.ncbi.nlm.nih.gov/pubmed/24802331
http://dx.doi.org/10.1038/jcbfm.2014.82
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author Gryglewski, Gregor
Lanzenberger, Rupert
Kranz, Georg S
Cumming, Paul
author_facet Gryglewski, Gregor
Lanzenberger, Rupert
Kranz, Georg S
Cumming, Paul
author_sort Gryglewski, Gregor
collection PubMed
description The success of serotonin-selective reuptake inhibitors has lent support to the monoamine theory of major depressive disorder (MDD). This issue has been addressed in a number of molecular imaging studies by positron emission tomography or single-photon emission computed tomography of serotonin reuptake sites (5-HTT) in the brain of patients with MDD, with strikingly disparate conclusions. Our meta-analysis of the 18 such studies, totaling 364 MDD patients free from significant comorbidities or medication and 372 control subjects, revealed reductions in midbrain 5-HTT (Hedges' g=−0.49; 95% CI: (−0.84, −0.14)) and amygdala (Hedges' g=−0.50; 95% CI: (−0.78, −0.22)), which no individual study possessed sufficient power to detect. Only small effect sizes were found in other regions with high binding (thalamus: g=−0.24, striatum: g=−0.32, and brainstem g=−0.22), and no difference in the frontal or cingulate cortex. Age emerged as an important moderator of 5-HTT availability in MDD, with more severe reductions in striatal 5-HTT evident with greater age of the study populations (P<0.01). There was a strong relationship between severity of depression and 5-HTT reductions in the amygdala (P=0.01). Thus, molecular imaging findings indeed reveal widespread reductions of ∼10% in 5-HTT availability in MDD, which may predict altered spatial–temporal dynamics of serotonergic neurotransmission.
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spelling pubmed-40833952014-07-10 Meta-analysis of molecular imaging of serotonin transporters in major depression Gryglewski, Gregor Lanzenberger, Rupert Kranz, Georg S Cumming, Paul J Cereb Blood Flow Metab Review Article The success of serotonin-selective reuptake inhibitors has lent support to the monoamine theory of major depressive disorder (MDD). This issue has been addressed in a number of molecular imaging studies by positron emission tomography or single-photon emission computed tomography of serotonin reuptake sites (5-HTT) in the brain of patients with MDD, with strikingly disparate conclusions. Our meta-analysis of the 18 such studies, totaling 364 MDD patients free from significant comorbidities or medication and 372 control subjects, revealed reductions in midbrain 5-HTT (Hedges' g=−0.49; 95% CI: (−0.84, −0.14)) and amygdala (Hedges' g=−0.50; 95% CI: (−0.78, −0.22)), which no individual study possessed sufficient power to detect. Only small effect sizes were found in other regions with high binding (thalamus: g=−0.24, striatum: g=−0.32, and brainstem g=−0.22), and no difference in the frontal or cingulate cortex. Age emerged as an important moderator of 5-HTT availability in MDD, with more severe reductions in striatal 5-HTT evident with greater age of the study populations (P<0.01). There was a strong relationship between severity of depression and 5-HTT reductions in the amygdala (P=0.01). Thus, molecular imaging findings indeed reveal widespread reductions of ∼10% in 5-HTT availability in MDD, which may predict altered spatial–temporal dynamics of serotonergic neurotransmission. Nature Publishing Group 2014-07 2014-05-07 /pmc/articles/PMC4083395/ /pubmed/24802331 http://dx.doi.org/10.1038/jcbfm.2014.82 Text en Copyright © 2014 International Society for Cerebral Blood Flow & Metabolism, Inc. http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Review Article
Gryglewski, Gregor
Lanzenberger, Rupert
Kranz, Georg S
Cumming, Paul
Meta-analysis of molecular imaging of serotonin transporters in major depression
title Meta-analysis of molecular imaging of serotonin transporters in major depression
title_full Meta-analysis of molecular imaging of serotonin transporters in major depression
title_fullStr Meta-analysis of molecular imaging of serotonin transporters in major depression
title_full_unstemmed Meta-analysis of molecular imaging of serotonin transporters in major depression
title_short Meta-analysis of molecular imaging of serotonin transporters in major depression
title_sort meta-analysis of molecular imaging of serotonin transporters in major depression
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083395/
https://www.ncbi.nlm.nih.gov/pubmed/24802331
http://dx.doi.org/10.1038/jcbfm.2014.82
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