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JNK3 Is Required for the Cytoprotective Effect of Exendin 4
Preservation of beta cell against apoptosis is one of the therapeutic benefits of the glucagon-like peptide-1 (GLP1) antidiabetic mimetics for preserving the functional beta cell mass exposed to diabetogenic condition including proinflammatory cytokines. The mitogen activated protein kinase 10 also...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083605/ https://www.ncbi.nlm.nih.gov/pubmed/25025079 http://dx.doi.org/10.1155/2014/814854 |
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author | Ezanno, Hélène Pawlowski, Valérie Abdelli, Saida Boutry, Raphael Gmyr, Valery Kerr-Conte, Julie Bonny, Christophe Pattou, François Abderrahmani, Amar |
author_facet | Ezanno, Hélène Pawlowski, Valérie Abdelli, Saida Boutry, Raphael Gmyr, Valery Kerr-Conte, Julie Bonny, Christophe Pattou, François Abderrahmani, Amar |
author_sort | Ezanno, Hélène |
collection | PubMed |
description | Preservation of beta cell against apoptosis is one of the therapeutic benefits of the glucagon-like peptide-1 (GLP1) antidiabetic mimetics for preserving the functional beta cell mass exposed to diabetogenic condition including proinflammatory cytokines. The mitogen activated protein kinase 10 also called c-jun amino-terminal kinase 3 (JNK3) plays a protective role in insulin-secreting cells against death caused by cytokines. In this study, we investigated whether the JNK3 expression is associated with the protective effect elicited by the GLP1 mimetic exendin 4. We found an increase in the abundance of JNK3 in isolated human islets and INS-1E cells cultured with exendin 4. Induction of JNK3 by exendin 4 was associated with an increased survival of INS-1E cells. Silencing of JNK3 prevented the cytoprotective effect of exendin 4 against apoptosis elicited by culture condition and cytokines. These results emphasize the requirement of JNK3 in the antiapoptotic effects of exendin 4. |
format | Online Article Text |
id | pubmed-4083605 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40836052014-07-14 JNK3 Is Required for the Cytoprotective Effect of Exendin 4 Ezanno, Hélène Pawlowski, Valérie Abdelli, Saida Boutry, Raphael Gmyr, Valery Kerr-Conte, Julie Bonny, Christophe Pattou, François Abderrahmani, Amar J Diabetes Res Research Article Preservation of beta cell against apoptosis is one of the therapeutic benefits of the glucagon-like peptide-1 (GLP1) antidiabetic mimetics for preserving the functional beta cell mass exposed to diabetogenic condition including proinflammatory cytokines. The mitogen activated protein kinase 10 also called c-jun amino-terminal kinase 3 (JNK3) plays a protective role in insulin-secreting cells against death caused by cytokines. In this study, we investigated whether the JNK3 expression is associated with the protective effect elicited by the GLP1 mimetic exendin 4. We found an increase in the abundance of JNK3 in isolated human islets and INS-1E cells cultured with exendin 4. Induction of JNK3 by exendin 4 was associated with an increased survival of INS-1E cells. Silencing of JNK3 prevented the cytoprotective effect of exendin 4 against apoptosis elicited by culture condition and cytokines. These results emphasize the requirement of JNK3 in the antiapoptotic effects of exendin 4. Hindawi Publishing Corporation 2014 2014-06-16 /pmc/articles/PMC4083605/ /pubmed/25025079 http://dx.doi.org/10.1155/2014/814854 Text en Copyright © 2014 Hélène Ezanno et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Ezanno, Hélène Pawlowski, Valérie Abdelli, Saida Boutry, Raphael Gmyr, Valery Kerr-Conte, Julie Bonny, Christophe Pattou, François Abderrahmani, Amar JNK3 Is Required for the Cytoprotective Effect of Exendin 4 |
title | JNK3 Is Required for the Cytoprotective Effect of Exendin 4 |
title_full | JNK3 Is Required for the Cytoprotective Effect of Exendin 4 |
title_fullStr | JNK3 Is Required for the Cytoprotective Effect of Exendin 4 |
title_full_unstemmed | JNK3 Is Required for the Cytoprotective Effect of Exendin 4 |
title_short | JNK3 Is Required for the Cytoprotective Effect of Exendin 4 |
title_sort | jnk3 is required for the cytoprotective effect of exendin 4 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083605/ https://www.ncbi.nlm.nih.gov/pubmed/25025079 http://dx.doi.org/10.1155/2014/814854 |
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