Lymphadenitis caused by infection with an isoniazid- and rifampin-resistant strain of Mycobacterium bovis BCG in an infant with IFN-γ/IL-12 pathway defect

We report a rare case in a female infant (age, 3.5 months) with primary immunodeficiency (IFN-γ/IL-12 pathway defect) who presented with suppurative lymphadenitis after Mycobacterium bovis BCG vaccination. The strain of M. bovis BCG identified was found to be resistant to isoniazid and rifampin. The...

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Autores principales: Diniz, Lilian Martins Oliveira, Guimarães, Tiago, de Oliveira, Maria das Graças Rodrigues, Pinto, Jorge Andrade, de Miranda, Silvana Spindola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Pneumologia e Tisiologia 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083635/
https://www.ncbi.nlm.nih.gov/pubmed/24831405
http://dx.doi.org/10.1590/S1806-37132014000200014
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author Diniz, Lilian Martins Oliveira
Guimarães, Tiago
de Oliveira, Maria das Graças Rodrigues
Pinto, Jorge Andrade
de Miranda, Silvana Spindola
author_facet Diniz, Lilian Martins Oliveira
Guimarães, Tiago
de Oliveira, Maria das Graças Rodrigues
Pinto, Jorge Andrade
de Miranda, Silvana Spindola
author_sort Diniz, Lilian Martins Oliveira
collection PubMed
description We report a rare case in a female infant (age, 3.5 months) with primary immunodeficiency (IFN-γ/IL-12 pathway defect) who presented with suppurative lymphadenitis after Mycobacterium bovis BCG vaccination. The strain of M. bovis BCG identified was found to be resistant to isoniazid and rifampin. The patient was treated with a special pharmacological regimen involving isoniazid (in a limited, strategic manner), ethambutol, streptomycin, and IFN-γ, after which there was complete resolution of the lesions.
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spelling pubmed-40836352014-07-16 Lymphadenitis caused by infection with an isoniazid- and rifampin-resistant strain of Mycobacterium bovis BCG in an infant with IFN-γ/IL-12 pathway defect Diniz, Lilian Martins Oliveira Guimarães, Tiago de Oliveira, Maria das Graças Rodrigues Pinto, Jorge Andrade de Miranda, Silvana Spindola J Bras Pneumol Case Report We report a rare case in a female infant (age, 3.5 months) with primary immunodeficiency (IFN-γ/IL-12 pathway defect) who presented with suppurative lymphadenitis after Mycobacterium bovis BCG vaccination. The strain of M. bovis BCG identified was found to be resistant to isoniazid and rifampin. The patient was treated with a special pharmacological regimen involving isoniazid (in a limited, strategic manner), ethambutol, streptomycin, and IFN-γ, after which there was complete resolution of the lesions. Sociedade Brasileira de Pneumologia e Tisiologia 2014 /pmc/articles/PMC4083635/ /pubmed/24831405 http://dx.doi.org/10.1590/S1806-37132014000200014 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Diniz, Lilian Martins Oliveira
Guimarães, Tiago
de Oliveira, Maria das Graças Rodrigues
Pinto, Jorge Andrade
de Miranda, Silvana Spindola
Lymphadenitis caused by infection with an isoniazid- and rifampin-resistant strain of Mycobacterium bovis BCG in an infant with IFN-γ/IL-12 pathway defect
title Lymphadenitis caused by infection with an isoniazid- and rifampin-resistant strain of Mycobacterium bovis BCG in an infant with IFN-γ/IL-12 pathway defect
title_full Lymphadenitis caused by infection with an isoniazid- and rifampin-resistant strain of Mycobacterium bovis BCG in an infant with IFN-γ/IL-12 pathway defect
title_fullStr Lymphadenitis caused by infection with an isoniazid- and rifampin-resistant strain of Mycobacterium bovis BCG in an infant with IFN-γ/IL-12 pathway defect
title_full_unstemmed Lymphadenitis caused by infection with an isoniazid- and rifampin-resistant strain of Mycobacterium bovis BCG in an infant with IFN-γ/IL-12 pathway defect
title_short Lymphadenitis caused by infection with an isoniazid- and rifampin-resistant strain of Mycobacterium bovis BCG in an infant with IFN-γ/IL-12 pathway defect
title_sort lymphadenitis caused by infection with an isoniazid- and rifampin-resistant strain of mycobacterium bovis bcg in an infant with ifn-γ/il-12 pathway defect
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083635/
https://www.ncbi.nlm.nih.gov/pubmed/24831405
http://dx.doi.org/10.1590/S1806-37132014000200014
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