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Adrenomedullin Deficiency and Aging Exacerbate Ischemic White Matter Injury after Prolonged Cerebral Hypoperfusion in Mice

Adrenomedullin was originally isolated from pheochromocytoma cells and reduces insulin resistance by decreasing oxidative stress. White matter lesions induced by aging and hyperglycemia play a crucial role in cognitive impairment in poststroke patients. Here, we examine whether adrenomedullin defici...

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Detalles Bibliográficos
Autores principales:	Mitome-Mishima, Yumiko, Miyamoto, Nobukazu, Tanaka, Ryota, Shimosawa, Tatsuo, Oishi, Hidenori, Arai, Hajime, Hattori, Nobutaka, Urabe, Takao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084515/ https://www.ncbi.nlm.nih.gov/pubmed/25028667 http://dx.doi.org/10.1155/2014/861632

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