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Role of IL-33 and Its Receptor in T Cell-Mediated Autoimmune Diseases
Interleukin-33 (IL-33) is a new cytokine of interleukin-1 family, whose specific receptor is ST2. IL-33 exerts its functions via its target cells and plays different roles in diseases. ST2 deletion and exclusion of IL-33/ST2 axis are accompanied by enhanced susceptibility to dominantly T cell-mediat...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084552/ https://www.ncbi.nlm.nih.gov/pubmed/25032216 http://dx.doi.org/10.1155/2014/587376 |
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author | Zhao, Qing Chen, Guangjie |
author_facet | Zhao, Qing Chen, Guangjie |
author_sort | Zhao, Qing |
collection | PubMed |
description | Interleukin-33 (IL-33) is a new cytokine of interleukin-1 family, whose specific receptor is ST2. IL-33 exerts its functions via its target cells and plays different roles in diseases. ST2 deletion and exclusion of IL-33/ST2 axis are accompanied by enhanced susceptibility to dominantly T cell-mediated organ-specific autoimmune diseases. It has been reported that IL-33/ST2 pathway plays a key role in host defense and immune regulation in inflammatory and infectious diseases. This review focuses on new findings in the roles of IL-33 and ST2 in several kinds of T cell-mediated autoimmune diseases. |
format | Online Article Text |
id | pubmed-4084552 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40845522014-07-16 Role of IL-33 and Its Receptor in T Cell-Mediated Autoimmune Diseases Zhao, Qing Chen, Guangjie Biomed Res Int Review Article Interleukin-33 (IL-33) is a new cytokine of interleukin-1 family, whose specific receptor is ST2. IL-33 exerts its functions via its target cells and plays different roles in diseases. ST2 deletion and exclusion of IL-33/ST2 axis are accompanied by enhanced susceptibility to dominantly T cell-mediated organ-specific autoimmune diseases. It has been reported that IL-33/ST2 pathway plays a key role in host defense and immune regulation in inflammatory and infectious diseases. This review focuses on new findings in the roles of IL-33 and ST2 in several kinds of T cell-mediated autoimmune diseases. Hindawi Publishing Corporation 2014 2014-06-16 /pmc/articles/PMC4084552/ /pubmed/25032216 http://dx.doi.org/10.1155/2014/587376 Text en Copyright © 2014 Q. Zhao and G. Chen. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Zhao, Qing Chen, Guangjie Role of IL-33 and Its Receptor in T Cell-Mediated Autoimmune Diseases |
title | Role of IL-33 and Its Receptor in T Cell-Mediated Autoimmune Diseases |
title_full | Role of IL-33 and Its Receptor in T Cell-Mediated Autoimmune Diseases |
title_fullStr | Role of IL-33 and Its Receptor in T Cell-Mediated Autoimmune Diseases |
title_full_unstemmed | Role of IL-33 and Its Receptor in T Cell-Mediated Autoimmune Diseases |
title_short | Role of IL-33 and Its Receptor in T Cell-Mediated Autoimmune Diseases |
title_sort | role of il-33 and its receptor in t cell-mediated autoimmune diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084552/ https://www.ncbi.nlm.nih.gov/pubmed/25032216 http://dx.doi.org/10.1155/2014/587376 |
work_keys_str_mv | AT zhaoqing roleofil33anditsreceptorintcellmediatedautoimmunediseases AT chenguangjie roleofil33anditsreceptorintcellmediatedautoimmunediseases |