Role of IL-33 and Its Receptor in T Cell-Mediated Autoimmune Diseases

Interleukin-33 (IL-33) is a new cytokine of interleukin-1 family, whose specific receptor is ST2. IL-33 exerts its functions via its target cells and plays different roles in diseases. ST2 deletion and exclusion of IL-33/ST2 axis are accompanied by enhanced susceptibility to dominantly T cell-mediat...

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Detalles Bibliográficos
Autores principales: Zhao, Qing, Chen, Guangjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084552/
https://www.ncbi.nlm.nih.gov/pubmed/25032216
http://dx.doi.org/10.1155/2014/587376
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author Zhao, Qing
Chen, Guangjie
author_facet Zhao, Qing
Chen, Guangjie
author_sort Zhao, Qing
collection PubMed
description Interleukin-33 (IL-33) is a new cytokine of interleukin-1 family, whose specific receptor is ST2. IL-33 exerts its functions via its target cells and plays different roles in diseases. ST2 deletion and exclusion of IL-33/ST2 axis are accompanied by enhanced susceptibility to dominantly T cell-mediated organ-specific autoimmune diseases. It has been reported that IL-33/ST2 pathway plays a key role in host defense and immune regulation in inflammatory and infectious diseases. This review focuses on new findings in the roles of IL-33 and ST2 in several kinds of T cell-mediated autoimmune diseases.
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spelling pubmed-40845522014-07-16 Role of IL-33 and Its Receptor in T Cell-Mediated Autoimmune Diseases Zhao, Qing Chen, Guangjie Biomed Res Int Review Article Interleukin-33 (IL-33) is a new cytokine of interleukin-1 family, whose specific receptor is ST2. IL-33 exerts its functions via its target cells and plays different roles in diseases. ST2 deletion and exclusion of IL-33/ST2 axis are accompanied by enhanced susceptibility to dominantly T cell-mediated organ-specific autoimmune diseases. It has been reported that IL-33/ST2 pathway plays a key role in host defense and immune regulation in inflammatory and infectious diseases. This review focuses on new findings in the roles of IL-33 and ST2 in several kinds of T cell-mediated autoimmune diseases. Hindawi Publishing Corporation 2014 2014-06-16 /pmc/articles/PMC4084552/ /pubmed/25032216 http://dx.doi.org/10.1155/2014/587376 Text en Copyright © 2014 Q. Zhao and G. Chen. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Zhao, Qing
Chen, Guangjie
Role of IL-33 and Its Receptor in T Cell-Mediated Autoimmune Diseases
title Role of IL-33 and Its Receptor in T Cell-Mediated Autoimmune Diseases
title_full Role of IL-33 and Its Receptor in T Cell-Mediated Autoimmune Diseases
title_fullStr Role of IL-33 and Its Receptor in T Cell-Mediated Autoimmune Diseases
title_full_unstemmed Role of IL-33 and Its Receptor in T Cell-Mediated Autoimmune Diseases
title_short Role of IL-33 and Its Receptor in T Cell-Mediated Autoimmune Diseases
title_sort role of il-33 and its receptor in t cell-mediated autoimmune diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084552/
https://www.ncbi.nlm.nih.gov/pubmed/25032216
http://dx.doi.org/10.1155/2014/587376
work_keys_str_mv AT zhaoqing roleofil33anditsreceptorintcellmediatedautoimmunediseases
AT chenguangjie roleofil33anditsreceptorintcellmediatedautoimmunediseases

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