Valproate pretreatment protects pancreatic β-cells from palmitate-induced ER stress and apoptosis by inhibiting glycogen synthase kinase-3β

BACKGROUND: Reduction of pancreatic β-cells mass, major secondary to increased β-cells apoptosis, is increasingly recognized as one of the main contributing factors to the pathogenesis of type 2 diabetes (T2D), and saturated free fatty acid palmitate has been shown to induce endoplasmic reticulum (E...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Shan, Zhu, Minghui, Wu, Wei, Rashid, Abid, Liang, Yan, Hou, Ling, Ning, Qin, Luo, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084580/
https://www.ncbi.nlm.nih.gov/pubmed/24884462
http://dx.doi.org/10.1186/1423-0127-21-38

Ejemplares similares

Ejemplares similares