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Novel Bioinformatics Method for Identification of Genome-Wide Non-Canonical Spliced Regions Using RNA-Seq Data

SETTING: During endoplasmic reticulum (ER) stress, the endoribonuclease (RNase) Ire1α initiates removal of a 26 nt region from the mRNA encoding the transcription factor Xbp1 via an unconventional mechanism (atypically within the cytosol). This causes an open reading frame-shift that leads to altere...

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Detalles Bibliográficos
Autores principales:	Bai, Yongsheng, Hassler, Justin, Ziyar, Ahdad, Li, Philip, Wright, Zachary, Menon, Rajasree, Omenn, Gilbert S., Cavalcoli, James D., Kaufman, Randal J., Sartor, Maureen A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084626/ https://www.ncbi.nlm.nih.gov/pubmed/24991935 http://dx.doi.org/10.1371/journal.pone.0100864

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