Enzymatic Glycosylation of Vancomycin Aglycon: Completion of a Total Synthesis of Vancomycin and N- and C-Terminus Substituent Effects of the Aglycon Substrate

[Image: see text] Studies on the further development of the sequential glycosylations of the vancomycin aglycon catalyzed by the glycosyltransferases GtfE and GtfD and the observation of unusual, perhaps unexpected, aglycon substrate substituent effects on the rate and efficiency of the initial glyc...

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Autores principales: Nakayama, Atsushi, Okano, Akinori, Feng, Yiqing, Collins, James C., Collins, Karen C., Walsh, Christopher T., Boger, Dale L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084835/
https://www.ncbi.nlm.nih.gov/pubmed/24954524
http://dx.doi.org/10.1021/ol501568t
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author Nakayama, Atsushi
Okano, Akinori
Feng, Yiqing
Collins, James C.
Collins, Karen C.
Walsh, Christopher T.
Boger, Dale L.
author_facet Nakayama, Atsushi
Okano, Akinori
Feng, Yiqing
Collins, James C.
Collins, Karen C.
Walsh, Christopher T.
Boger, Dale L.
author_sort Nakayama, Atsushi
collection PubMed
description [Image: see text] Studies on the further development of the sequential glycosylations of the vancomycin aglycon catalyzed by the glycosyltransferases GtfE and GtfD and the observation of unusual, perhaps unexpected, aglycon substrate substituent effects on the rate and efficiency of the initial glycosylation reaction are reported.
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spelling pubmed-40848352014-07-09 Enzymatic Glycosylation of Vancomycin Aglycon: Completion of a Total Synthesis of Vancomycin and N- and C-Terminus Substituent Effects of the Aglycon Substrate Nakayama, Atsushi Okano, Akinori Feng, Yiqing Collins, James C. Collins, Karen C. Walsh, Christopher T. Boger, Dale L. Org Lett [Image: see text] Studies on the further development of the sequential glycosylations of the vancomycin aglycon catalyzed by the glycosyltransferases GtfE and GtfD and the observation of unusual, perhaps unexpected, aglycon substrate substituent effects on the rate and efficiency of the initial glycosylation reaction are reported. American Chemical Society 2014-06-23 2014-07-03 /pmc/articles/PMC4084835/ /pubmed/24954524 http://dx.doi.org/10.1021/ol501568t Text en Copyright © 2014 American Chemical Society Terms of Use (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html)
spellingShingle Nakayama, Atsushi
Okano, Akinori
Feng, Yiqing
Collins, James C.
Collins, Karen C.
Walsh, Christopher T.
Boger, Dale L.
Enzymatic Glycosylation of Vancomycin Aglycon: Completion of a Total Synthesis of Vancomycin and N- and C-Terminus Substituent Effects of the Aglycon Substrate
title Enzymatic Glycosylation of Vancomycin Aglycon: Completion of a Total Synthesis of Vancomycin and N- and C-Terminus Substituent Effects of the Aglycon Substrate
title_full Enzymatic Glycosylation of Vancomycin Aglycon: Completion of a Total Synthesis of Vancomycin and N- and C-Terminus Substituent Effects of the Aglycon Substrate
title_fullStr Enzymatic Glycosylation of Vancomycin Aglycon: Completion of a Total Synthesis of Vancomycin and N- and C-Terminus Substituent Effects of the Aglycon Substrate
title_full_unstemmed Enzymatic Glycosylation of Vancomycin Aglycon: Completion of a Total Synthesis of Vancomycin and N- and C-Terminus Substituent Effects of the Aglycon Substrate
title_short Enzymatic Glycosylation of Vancomycin Aglycon: Completion of a Total Synthesis of Vancomycin and N- and C-Terminus Substituent Effects of the Aglycon Substrate
title_sort enzymatic glycosylation of vancomycin aglycon: completion of a total synthesis of vancomycin and n- and c-terminus substituent effects of the aglycon substrate
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084835/
https://www.ncbi.nlm.nih.gov/pubmed/24954524
http://dx.doi.org/10.1021/ol501568t
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